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神経膠腫に対するACNUおよび5-FUの効果
http://hdl.handle.net/2297/40414
http://hdl.handle.net/2297/404146840f97d-ab8c-49ab-8c1b-a2581eed6fe5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-YAMASHIMA-T-140.pdf (481.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | 神経膠腫に対するACNUおよび5-FUの効果 | |||||
| タイトル | ||||||
| タイトル | Evaluation of ACNU and 5-FU in the Treatment of Gliomas | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
河野, 寛一
× 河野, 寛一× 久保田, 紀彦× 林, 実× 山本, 信二郎× 山嶋, 哲盛× 伊藤, 治英× 古林, 秀則× 半田, 裕二× 兜, 正則× 石倉, 彰× 村田, 秀秋× 羽場, 勝彦× 駒井, 杜詩夫 |
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| 書誌情報 |
Neurologia medico-chirurgica = 神経外科 巻 26, 号 2, p. 140-146, 発行日 1986-01-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0470-8105 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA1202239X | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2176/nmc.26.140 | |||||
| 出版者 | ||||||
| 出版者 | 日本脳神経外科学会 = The Japan Neurosurgical Society | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Combination therapy with radiation and (1-4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)3-nitrosourea hydrochloride (ACNU) and/or N1-(2'-tetrahydrofuryl)-5-fluorouracil (5-FU) was given to 102 patients with malignant gliomas. The purpose of this study was to evaluate the efficacy of two treatment protocols after operative resection as compared with the control treatment, radiotherapy+5-FU. The three protocols were (A): adequate operation (OP)+radiation (R) (40-60 Grey/6-7 weeks)+ACNU [1-3 mg/kg, intravenously (IV) or intraarterially (IA), two times with a week interval, and repeated after 6 months]±OK-432 (2.0 “Klinische Einheit” or clinical unit/week, intramuscularly), (B): OP+R+ACNU (1-3 mg/kg, IV or IA, two times with 6-8 weeks interval, and repeated after 6 months)+5-FU (8-16 mg/kg/day orally)±OK-432, (C): OP+R+5-FU. The combination therapy with ACNU and radiation significantly improved survival time as compared with protocol (C) (p<0.01). Malignant gliomas treated with protocol (A) had 40.5 months mean survival time (MST) and (B) had 25.7 months MST. On the other hand (C) group had a MST of 11.3 months (A:B, not significant, A:C p=0.00, B:C p=0.0002). Several important prognostic factors were identified. Histological type, initial performance status and operative resections were significant factors but ACNU total dosage, administration route and OK-432 had no influence on the survival after surgery. Nausea and vomiting were noticed immediately after ACNU administration, and later myelosuppression occurred in 25-29% of the patients. No relationship was observed between toxicity, and the single dosage of ACNU or administration routes. | |||||
| 権利 | ||||||
| 権利情報 | Copyright © The Japan Neurosurgical Society 日本脳神経外科学会 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/browse/nmc | |||||
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| 識別子タイプ | URI | |||||
| 関連識別子 | http://jns.umin.ac.jp/ | |||||
