@article{oai:kanazawa-u.repo.nii.ac.jp:00014064,
 author = {Ishikawa, Kazuya and Yagi-Nakanishi, Sayaka and Nakanishi, Yosuke and Kondo, Satoru and Tsuji, Akira and Endo, Kazuhira and Wakisaka, Naohiro and Murono, Shigeyuki and Yoshizaki, Tomokazu},
 issue = {6},
 journal = {Auris Nasus Larynx},
 month = {Jan},
 note = {Objective: The aim of this study was to clarify the role of IL-33 in tumor progression. Methods: Surgical specimens from 81 patients with squamous cell carcinoma of the tongue were studied using immunohistochemistry. Primary tumor sections were analyzed for IL-33 and ST2 expression. To examine the influence of IL-33 on the microenvironment of the tumor, we determined the mast cell density (MCD) and microvessel density of the stroma. Results: Patients with high IL-33 expression had a significantly worse prognosis (p = 0.004). IL-33 expression was significantly elevated in patients with local and nodal recurrence (p = 0.014 and p = 0.019). ST2 expression was also associated with a worse prognosis (p = 0.024) and was significantly elevated in patients with nodal recurrence (p = 0.004). MCD was associated with worse prognosis (p = 0.038) and correlated significantly with IL-33 expression (r = 0.626, p < 0.001). Micovessels in the stroma were significantly increased in the high IL-33 group (p < 0.001). Conclusion: These data suggest that the IL-33/ST2 axis contributes to tumor aggressiveness and affects the tumor microenvironment. Immunohistochemical evaluation of IL-33 and ST2 is useful for identifying patients at a high risk for poor prognosis. © 2014 Elsevier Ireland Ltd. All rights reserved.},
 pages = {552--557},
 title = {Expression of interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue},
 volume = {41},
 year = {2014}
}