{"created":"2023-07-27T06:29:18.375722+00:00","id":14064,"links":{},"metadata":{"_buckets":{"deposit":"fe096a0e-61e6-4d19-a43d-e87998e908c1"},"_deposit":{"created_by":3,"id":"14064","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14064"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014064","sets":["1132:1133:1134"]},"author_link":["23950","23948","21465","20177","20582","22167","23949","79","21455"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"557","bibliographicPageStart":"552","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"Auris Nasus Larynx"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: The aim of this study was to clarify the role of IL-33 in tumor progression. Methods: Surgical specimens from 81 patients with squamous cell carcinoma of the tongue were studied using immunohistochemistry. Primary tumor sections were analyzed for IL-33 and ST2 expression. To examine the influence of IL-33 on the microenvironment of the tumor, we determined the mast cell density (MCD) and microvessel density of the stroma. Results: Patients with high IL-33 expression had a significantly worse prognosis (p = 0.004). IL-33 expression was significantly elevated in patients with local and nodal recurrence (p = 0.014 and p = 0.019). ST2 expression was also associated with a worse prognosis (p = 0.024) and was significantly elevated in patients with nodal recurrence (p = 0.004). MCD was associated with worse prognosis (p = 0.038) and correlated significantly with IL-33 expression (r = 0.626, p < 0.001). Micovessels in the stroma were significantly increased in the high IL-33 group (p < 0.001). Conclusion: These data suggest that the IL-33/ST2 axis contributes to tumor aggressiveness and affects the tumor microenvironment. Immunohistochemical evaluation of IL-33 and ST2 is useful for identifying patients at a high risk for poor prognosis. © 2014 Elsevier Ireland Ltd. All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.anl.2014.08.007","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00061157","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-8146","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishikawa, Kazuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yagi-Nakanishi, Sayaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakanishi, Yosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kondo, Satoru"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Tsuji, Akira"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Endo, Kazuhira"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Wakisaka, Naohiro"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Murono, Shigeyuki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yoshizaki, Tomokazu"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-YOSHIZAKI-ISHIKAWA-552.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-YOSHIZAKI-ISHIKAWA-552.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14064/files/ME-PR-YOSHIZAKI-ISHIKAWA-552.pdf"},"version_id":"5e93e271-bc52-402f-8351-e090e0da8070"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Expression of interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14064","relation_version_is_last":true,"title":["Expression of interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:53:33.628395+00:00"}