{"created":"2023-07-27T06:29:18.955776+00:00","id":14077,"links":{},"metadata":{"_buckets":{"deposit":"42a68b48-cad8-483c-b210-58b44d22f365"},"_deposit":{"created_by":3,"id":"14077","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14077"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014077","sets":["1132:1133:1134"]},"author_link":["124","110","24006","24007","2907","24008","23232","154","2843"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-07-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"1020","bibliographicPageStart":"1016","bibliographicVolumeNumber":"450","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"滝野, 隆久"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"中田, 光俊"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"堂本, 貴寛"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"川尻, 秀一"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"佐藤, 博"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Fibronectin matrix formation requires the increased cytoskeletal tension generated by cadherin adhesions, and is suppressed by membrane-type 1 matrix metalloproteinase (MT1-MMP). In a co-culture of Rat1 fibroblasts and MT1-MMP-silenced HT1080 cells, fibronectin fibrils extended from Rat1 to cell-matrix adhesions in HT1080 cells, and N-cadherin adhesions were formed between Rat1 and HT1080 cells. In control HT1080 cells contacting with Rat1 fibroblasts, cell-matrix adhesions were formed in the side away from Rat1 fibroblasts, and fibronectin assembly and N-cadherin adhesions were not formed. The role of N-cadherin adhesions in fibronectin matrix formation was studied using MT1-MMP-silenced HT1080 cells. MT1-MMP knockdown promoted fibronectin matrix assembly and N-cadherin adhesions in HT1080 cells, which was abrogated by double knockdown with either integrin β1 or fibronectin. Conversely, inhibition of N-cadherin adhesions by its knockdown or treatment with its neutralizing antibody suppressed fibronectin matrix formation in MT1-MMP-silenced cells. These results demonstrate that fibronectin assembly initiated by MT1-MMP knockdown results in increase of N-cadherin adhesions, which are prerequisite for further fibronectin matrix formation. © 2014 Elsevier Inc. All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00014064","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Academic Press"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2014.06.100","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11542044","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1090-2104","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takino, Takahisa"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Yoshimoto, Taisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakada, Mitsutoshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Li, Zichen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Domoto, Takahiro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Kawashiri, Shuici"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Sato, Hiroshi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"CA-PR-TAKINO-T-1016.pdf","filesize":[{"value":"921.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-TAKINO-T-1016.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14077/files/CA-PR-TAKINO-T-1016.pdf"},"version_id":"05531484-01b3-4c6f-b643-324a6fcd6457"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Membrane-type 1 matrix metalloproteinase regulates fibronectin assembly and N-cadherin adhesion","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Membrane-type 1 matrix metalloproteinase regulates fibronectin assembly and N-cadherin adhesion"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14077","relation_version_is_last":true,"title":["Membrane-type 1 matrix metalloproteinase regulates fibronectin assembly and N-cadherin adhesion"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T08:46:38.892776+00:00"}