{"created":"2023-07-27T06:29:19.713626+00:00","id":14094,"links":{},"metadata":{"_buckets":{"deposit":"3349ca10-296c-42e0-a5ce-fa58758a45dd"},"_deposit":{"created_by":3,"id":"14094","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14094"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014094","sets":["1132:1133:1134"]},"author_link":["24035","20075","92"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"532","bibliographicPageStart":"527","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"胆と膵 = The Biliary tract & pancreas"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝内結石症に合併する肝内胆管癌は多段階発癌を示す. 2つの前癌病変が知られており, 平坦な増殖を特徴とする胆管上皮層内腫瘍性病変biliary intraepithelial neoplasia(BilIN)と胆管内乳頭状腫瘍である. BilIN分類では, BilIN-1が低異型度病変, BilIN-2が高異型度病変, BilIN-3は上皮内癌carcinoma in situである. BilINではその進展過程において, p21の過剰発現, cyclin D1の発現亢進がみられ, さらにMUC1, p53, MMP7, MT1-MMPはBilINの進展過程で後期に過剰発現がみられ, 浸潤部で高率に発現を示した. smad4, β-cateninやE-cadherinはBilIN病変の進展と伴に発現が減少した. BilIN分類を用いることにより, 肝内結石症に合併する発癌機序を明らかにできると期待される.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"医学図書出版"}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.igakutosho.co.jp/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.igakutosho.co.jp/magazine/t_s/2014/zt35s.html","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 医学図書出版 | 許可を得て登録"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00333226","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0388-9408","subitem_source_identifier_type":"ISSN"}]},"item_4_text_2":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"[特集]肝内結石症:最近の知見"},{"subitem_text_value":"Cholangiocarcinogenesis in Hepatolithaisis:　Proposal of Biliary lntraepithelial Neoplasia　Classification for Preneoplastic and Early　Neopalstic　Biliary　Lesion"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中沼, 安二"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"板津, 慶太"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"全, 陽"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-NAKANUMA-Y-527.pdf","filesize":[{"value":"5.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-NAKANUMA-Y-527.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14094/files/ME-PR-NAKANUMA-Y-527.pdf"},"version_id":"b9915aa9-3b5b-418e-b604-95bb1533baec"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"肝内結石症における肝内胆管癌発生のプロセス:胆管上皮層内腫瘍性病変BilIN分類の提案","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝内結石症における肝内胆管癌発生のプロセス:胆管上皮層内腫瘍性病変BilIN分類の提案"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14094","relation_version_is_last":true,"title":["肝内結石症における肝内胆管癌発生のプロセス:胆管上皮層内腫瘍性病変BilIN分類の提案"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:53:06.945981+00:00"}