{"created":"2023-07-27T06:29:19.802934+00:00","id":14096,"links":{},"metadata":{"_buckets":{"deposit":"1912e5b8-6b88-4f28-8e1d-0ef30695332f"},"_deposit":{"created_by":3,"id":"14096","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14096"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014096","sets":["1132:1133:1134"]},"author_link":["362","20454","24044","20455","24042","24043","24045","357"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-07-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"695","bibliographicPageStart":"689","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"International Journal of Urology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: To determine testosterone fractions in Japanese men and to compare these values with those of Framingham Heart Study participants. Methods: We enrolled 498 healthy Japanese men. Total testosterone was assayed by liquid chromatography tandem mass spectrometry, sex hormone-binding globulin was assayed by immunoassay and free testosterone was calculated by a laboratory at the Boston Medical Center. Analog-based free testosterone and immunoassay-based total testosterone were determined by immunoassay. We compared mass spectrometry assay-based total testosterone and calculated free testosterone values in the Japanese participants with values in the American Framingham Heart Study third generation cohort. Results: The mean serum mass spectrometry assay-based total testosterone, sex hormone-binding globulin, and calculated free testosterone values were 439.4±167ng/dL, 65.34±30.61nmol/L, and 58.75±20.0pg/mL, respectively. The correlation coefficients with age for mass spectrometry assay-based total testosterone, sex hormone-binding globulin, and calculated free testosterone were 0.0010, 0.5041, and -0.496, respectively. There were no age-related changes in mass spectrometry assay-based total testosterone values in healthy men (P=0.981), whereas sex hormone-binding globulin and calculated free testosterone levels showed similar age-related changes (P<0.0001). Serum analog-based free testosterone levels (8.24±2.9pg/mL) showed age-related changes (P<0.0001) regardless of immunoassay-based total testosterone levels (P=0.828). Serum immunoassay-based total testosterone values (486.1±162.5ng/dL) correlated with serum mass spectrometry assay-based total testosterone values (r=0.740, 95% confidence interval 0.6965-0.7781, P<0.0001). Similarly, analog-based free testosterone and calculated free testosterone values showed a highly significant correlation (r=0.706, 95% confidence interval 0.6587-0.7473, P<0.0001). The analog-based free testosterone values were approximately 10% of the calculated free testosterone values. Conclusions: In contrast to the Framingham Heart Study cohort, total testosterone values in Japanese men are not associated with advancing age; thus, they cannot be used to diagnose late-onset hypogonadism in Japan. The analog-based free testosterone value can be considered instead as a suitable biochemical determinant for diagnosing late-onset hypogonadism syndrome. © 2014 The Japanese Urological Association.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Urological Association 日本泌尿器科学会 / Wiley-Blackwell"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/iju.12393","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.urol.or.jp/","subitem_relation_type_select":"URI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11042471","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0919-8172","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Taya, Masaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koh, Eitetsu"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Izumi, Kouji"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Iijima, Masashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maeda, Yuji"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Matsushita, Tomohiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwamoto, Teruaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Namiki, Mikio"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-KOH-E-689.pdf","filesize":[{"value":"510.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-KOH-E-689.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14096/files/ME-PR-KOH-E-689.pdf"},"version_id":"0560278d-7f79-4827-ad6e-6d490b135ea4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Comparison of testosterone fractions between Framingham Heart Study participants and Japanese participants","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparison of testosterone fractions between Framingham Heart Study participants and Japanese participants"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14096","relation_version_is_last":true,"title":["Comparison of testosterone fractions between Framingham Heart Study participants and Japanese participants"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:53:04.097913+00:00"}