{"created":"2023-07-27T06:29:21.272472+00:00","id":14129,"links":{},"metadata":{"_buckets":{"deposit":"c2010b47-c12f-4574-aaa9-b15a584fe415"},"_deposit":{"created_by":3,"id":"14129","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14129"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014129","sets":["1132:1133:1134"]},"author_link":["24130","24126","24133","24127","24131","24134","24128","24132","334","24129","24135"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageStart":"e1004780","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"PLoS Pathogens"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Transforming growth factor (TGF)-β inhibits hepatitis B virus (HBV) replication although the intracellular effectors involved are not determined. Here, we report that reduction of HBV transcripts by TGF-β is dependent on AID expression, which significantly decreases both HBV transcripts and viral DNA, resulting in inhibition of viral replication. Immunoprecipitation reveals that AID physically associates with viral P protein that binds to specific virus RNA sequence called epsilon. AID also binds to an RNA degradation complex (RNA exosome proteins), indicating that AID, RNA exosome, and P protein form an RNP complex. Suppression of HBV transcripts by TGF-β was abrogated by depletion of either AID or RNA exosome components, suggesting that AID and the RNA exosome involve in TGF-β mediated suppression of HBV RNA. Moreover, AID-mediated HBV reduction does not occur when P protein is disrupted or when viral transcription is inhibited. These results suggest that induced expression of AID by TGF-β causes recruitment of the RNA exosome to viral RNP complex and the RNA exosome degrades HBV RNA in a transcription-coupled manner. © 2015 Liang et al.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.ppat.1004780","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004780","subitem_relation_type_select":"URI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1553-7366","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Liang, Guoxin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Liu, Guangyan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitamura, Kouichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wang, Zhe"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chowdhury, Sajeda"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Md Monjurul, Ahasan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wakae, Kousho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koura, Miki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimadu, Miyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kinoshita, Kazuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Muramatsu, Masamichi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-MATSUMURA-M-e1004780.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-MATSUMURA-M-e1004780.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14129/files/ME-PR-MATSUMURA-M-e1004780.pdf"},"version_id":"085a4e55-158b-4fc3-8db0-d94154dd21d0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"TGF-β Suppression of HBV RNA through AID-Dependent Recruitment of an RNA Exosome Complex","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"TGF-β Suppression of HBV RNA through AID-Dependent Recruitment of an RNA Exosome Complex"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14129","relation_version_is_last":true,"title":["TGF-β Suppression of HBV RNA through AID-Dependent Recruitment of an RNA Exosome Complex"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:52:26.248932+00:00"}