{"created":"2023-07-27T06:29:21.494240+00:00","id":14134,"links":{},"metadata":{"_buckets":{"deposit":"360e6b16-6b14-4ef8-ad33-eef740cf45d8"},"_deposit":{"created_by":3,"id":"14134","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14134"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014134","sets":["1132:1133:1134"]},"author_link":["22901","914","24148","1578","245","1009","406","508"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"236","bibliographicPageStart":"231","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"Pathology International"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A needle biopsy of a mass in the right breast of a 36-year-old woman revealed invasive ductal carcinoma (IDC), and approximately 20% of cancer cells showed unequivocal membranous staining with the HercepTest. After systemic therapy with trastuzumab and paclitaxel followed by FEC (fluorouracil + epirubicin + cyclophosphamide), a right mastectomy was performed. By histological and immunohistochemical examinations, the resected tumor consisted mainly of E-cadherin-negative invasive lobular carcinoma (ILC), and the rest was ERBB2-positive IDC; thus, the diagnosis was mixed ductal and lobular carcinoma. Multiplex ligation-dependent probe amplification and fluorescence in situ hybridization (FISH) analyses revealed that ILC and IDC shared high-level amplification of CCND1 in homogeneously staining regions (HSR) and that IDC had an additional HSR-type amplicon of ERBB2. These findings strongly indicate that IDC and ILC had a common precursor cell with CCND1 amplification. Review of the biopsy specimen with FISH showed IDC with gene amplifications of CCND1 and ERBB2 as a minor component, IDC without amplification of CCND1 or ERBB2 as a major component, and a minute portion of ILC with CCND1 amplification. We speculate that chemotherapy and trastuzumab caused a marked reduction in IDC; however, ILC with CCND1 amplification was resistant to chemotherapy and grew. © 2014 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Blackwell Publishing"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/pin.12158","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11631315","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1440-1827","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tajiri, Ryosuke"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Inokuchi, Masafumi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Sawada-Kitamura, Seiko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kawashima, Hiroko"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Nakamura, Ritsuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oyama, Takeru"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Dobashi, Yoh"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Ooi, Akishi"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-OOI-A-231.pdf","filesize":[{"value":"598.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-OOI-A-231.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14134/files/ME-PR-OOI-A-231.pdf"},"version_id":"043d5b0d-5336-4aa9-b8f6-5c35db368786"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clonal profiling of mixed lobular and ductal carcinoma revealed by multiplex ligation-dependent probe amplification and fluorescence in situ hybridization","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clonal profiling of mixed lobular and ductal carcinoma revealed by multiplex ligation-dependent probe amplification and fluorescence in situ hybridization"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14134","relation_version_is_last":true,"title":["Clonal profiling of mixed lobular and ductal carcinoma revealed by multiplex ligation-dependent probe amplification and fluorescence in situ hybridization"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:52:20.529505+00:00"}