{"created":"2023-07-27T06:29:22.448367+00:00","id":14157,"links":{},"metadata":{"_buckets":{"deposit":"eb90d8ec-1b78-4ad4-b533-e26c003c04ff"},"_deposit":{"created_by":3,"id":"14157","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14157"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014157","sets":["1132:1133:1134"]},"author_link":["24218","20075","24219","249","642","182","129","1009","92"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"341","bibliographicPageStart":"335","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"胆と膵 = The Biliary tract & pancreas"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝内胆管上皮のheterogeneityを病理形態学の観点から解説した. 正常の肝内胆管系の胆管上皮では, 解剖学的なレベルに応じた形態学的特徴に加え, 酵素や血液型物質の分布に違いがあり, 粘液や抗菌ペプチドは主に肝内大型胆管や隔壁性胆管に発現する. また, 網羅的な遺伝子解析により, 胆管の解剖学的なレベルにより発現する遺伝子の違いも報告されている. 肝内胆管癌は, 肝内胆管系の種々の解剖学的部位から発生するが, 正常胆管にみられるこれらの形質が, 癌化後も発現し, 生物学的特性に関連している可能性が高い. 病的な肝内胆管では, 粘液プロフィルや化生等の形質発現にheterogeneityがみられ, 発癌との関連性が示唆されている. 特に, 胆管上皮の腸上皮化生とCDX2の異常発現との関連性が注目されている. 末梢型肝内胆管癌と増生細胆管の形質に類似しており, 肝progenitor細胞が発癌に関連する可能性がある.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"医学図書出版"}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.igakutosho.co.jp/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.igakutosho.co.jp/magazine/t_s/2014/zt35s.html","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 医学図書出版 | 許可を得て登録"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00333226","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0388-9408","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中沼, 安二"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"池田, 博子"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"佐々木, 素子"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"小坂, 一斗"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"原田, 憲一"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"一瀬, 久美子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐藤, 保則"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"澤田, 星子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"全, 陽"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-NAKANUMA-Y-335.pdf","filesize":[{"value":"4.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-NAKANUMA-Y-335.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14157/files/ME-PR-NAKANUMA-Y-335.pdf"},"version_id":"96ad78cf-4635-40cf-a966-079861fac0ee"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"病理形態学的観点よりみた胆管上皮のHeterogeneity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"病理形態学的観点よりみた胆管上皮のHeterogeneity"},{"subitem_title":"Heterogeneity of Biliary Epithelial Cells from 　the Pathological Standpoint of View","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14157","relation_version_is_last":true,"title":["病理形態学的観点よりみた胆管上皮のHeterogeneity"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:51:56.556416+00:00"}