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Cellular clocks in AVP neurons of the scn are critical for interneuronal coupling regulating circadian behavior rhythm
http://hdl.handle.net/2297/41375
http://hdl.handle.net/2297/413755658628a-629d-4808-8eef-e5fbc60ee02d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-MIEDA-M-1103.pdf (35.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Cellular clocks in AVP neurons of the scn are critical for interneuronal coupling regulating circadian behavior rhythm | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Mieda, Michihiro
× Mieda, Michihiro× Ono, Daisuke× Hasegawa, Emi× Okamoto, Hitoshi× Honma, Ken-ichi× Honma, Sato× Sakurai, Takeshi |
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| 書誌情報 |
Neuron 巻 85, 号 5, p. 1103-1116, 発行日 2015-03-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0896-6273 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10736690 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.neuron.2015.02.005 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier Cell Press | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, is a network structure composed of multiple types of neurons. Here, we report that mice with a Bmal1 deletion specific to arginine vasopressin (AVP)-producing neurons showed marked lengthening in the free-running period and activity time of behavior rhythms. When exposed to an abrupt 8-hr advance of the light/dark cycle, these mice reentrained faster than control mice did. In these mice, the circadian expression of genes involved in intercellular communications, including Avp, Prokineticin 2, and Rgs16, was drastically reduced in the dorsal SCN, where AVP neurons predominate. In slices, dorsal SCN cells showed attenuated PER2::LUC oscillation with highly variable and lengthened periods. Thus, Bmal1-dependent oscillators of AVP neurons may modulate the coupling of the SCN network, eventually coupling morning and evening behavioral rhythms, by regulating expression of multiple factors important for the network property of these neurons. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.elsevier.com/locate/issn/08966273 | |||||
