{"created":"2023-07-27T06:29:23.175634+00:00","id":14174,"links":{},"metadata":{"_buckets":{"deposit":"e8392dee-71c8-437e-b5ca-5c8584c54045"},"_deposit":{"created_by":3,"id":"14174","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14174"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014174","sets":["1132:1133:1134"]},"author_link":["24261","980","24265","24264","594","62","24262","24263","670"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"711","bibliographicPageStart":"706","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"Journal of Cardiology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Atrial fibrosis is a hallmark of atrial structural remodeling leading to the persistence of atrial fibrillation. Although fibroblasts play a major role in atrial fibrosis, their source in the adult atrium is unclear. We tested the hypothesis that endothelial cells contribute to fibroblast accumulation through an endothelial-mesenchymal transition in the atrium of patients with atrial fibrillation. Methods and results: The study group consisted of patients with atrial fibrillation and valvular disease or atrial septal defect who underwent left atrial appendectomy during cardiac surgery (n =38). The amount of fibrotic depositions in the left atrium positively correlated with left atrial dimension. Furthermore, snail and S100A4, indicative of endothelial-mesenchymal transition, were quantified in the left atrium using western blot analysis, which showed statistically significant correlations with left atrial dimension. Immunofluorescence assay of the left atrial tissue identified snail and S100A4 being expressed within the endocardium which is composed of CD31+ cells. The snail-positive endocardium also showed the expression of membrane type 1-matrix metalloproteinase. Immunofluorescence multi-labeling experiments identified that heat shock protein 47, prolyl-4-hydroxylase, and procollagen type 1 co-localized with snail and S100A4 within the endothelial cells of the left atrium, indicating the mesenchymal phenotype to produce collagen. Conclusions: In this study, we showed that the endothelial-mesenchymal transition occurs in the atrium of patients with atrial fibrillation. This observation should help in constructing a novel therapeutic approach for preventing atrial structural remodeling. © 2016 Japanese College of Cardiology.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese College of Cardiology = 日本心臓病学会"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jjcc.2016.10.014","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jcc.gr.jp/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2016 Japanese College of Cardiology | This is the author's version of a work accepted for publication by Japanese College of Cardiology. Changes resulting from the publishing process, including peer review, editing, corrections, structural formatting and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. The definitive version has been published in Journal of Cardiology, Volume 69, Issue 5, May 2017, http://dx.doi.org/10.1016/j.jjcc.2016.10.014"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN10070473","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0914-5087","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kato, Takeshi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Sekiguchi, Akiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sagara, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanabe, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takamura, Masayuki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Kaneko, Shuichi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Aizawa, Tadanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fu, Long-Tai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Takeshi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-KATO-T-706.pdf","filesize":[{"value":"731.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-KATO-T-706.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14174/files/ME-PR-KATO-T-706.pdf"},"version_id":"faa9ff97-b80c-47cb-851f-1110b96e19f4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Endothelial-mesenchymal transition in human atrial fibrillation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Endothelial-mesenchymal transition in human atrial fibrillation"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14174","relation_version_is_last":true,"title":["Endothelial-mesenchymal transition in human atrial fibrillation"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:51:38.232978+00:00"}