{"created":"2023-07-27T06:29:23.735971+00:00","id":14187,"links":{},"metadata":{"_buckets":{"deposit":"8c2ef72d-9376-4aa5-8509-23eb094b6b32"},"_deposit":{"created_by":3,"id":"14187","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14187"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014187","sets":["1132:1133:1134"]},"author_link":["47","20436","24315","151","44"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"801","bibliographicPageStart":"795","bibliographicVolumeNumber":"68","bibliographic_titles":[{"bibliographic_title":"Archives of Biological Sciences"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cyclic adenosine monophosphate (cAMP) controls differentiation in several types of cells during brain development. However, the molecular mechanism of cAMP-controlled differentiation is not fully understood. We investigated the role of protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac) on cAMP-induced glial fibrillary acidic protein (GFAP), an astrocyte marker, in cultured glial cells. B92 glial cells were treated with cAMP-elevating drugs, an activator of adenylate cyclase, phosphodiesterase inhibitor and a β adrenal receptor agonist. These cAMP-elevating agents induced dramatic morphological changes and expression of GFAP. A cAMP analog, 8-Br-cAMP, which activates Epac as well as PKA, induced GFAP expression and morphological changes, while another cAMP analog, 8-CPT-cAMP, which activates Epac with greater efficacy when compared to PKA, induced GFAP expression but very weak morphological changes. Most importantly, the treatment with a PKA inhibitor partially reduced cAMP-induced GFAP expression. Taken together, these results indicate that cAMP-elevating drugs lead to the induction of GFAP via PKA and/or Epac activation in B92 glial cells. © 2016 by the Serbian Biological Society.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Serbian Biological Society / Institut za Bioloska Istrazivanja"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2298/ABS160112067S","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00547181","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0354-4664","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sugimoto, Naotoshi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Miwa, Shinji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Hiroyuki"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Tsuchiya, Hiroyuki"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Yachie, Akihiro"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-SUGIMOTO-N-795.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-SUGIMOTO-N-795.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14187/files/ME-PR-SUGIMOTO-N-795.pdf"},"version_id":"801a7564-18a6-4f47-b493-1350eacdef73"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Protein kinase A and Epac activation by cAMP regulateS the expression of glial fibrillary acidic protein in glial cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Protein kinase A and Epac activation by cAMP regulateS the expression of glial fibrillary acidic protein in glial cells"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14187","relation_version_is_last":true,"title":["Protein kinase A and Epac activation by cAMP regulateS the expression of glial fibrillary acidic protein in glial cells"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:51:24.418351+00:00"}