{"created":"2023-07-27T06:29:23.868261+00:00","id":14189,"links":{},"metadata":{"_buckets":{"deposit":"0c2dd9ed-ecb1-45d7-b414-79461b763c54"},"_deposit":{"created_by":3,"id":"14189","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14189"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014189","sets":["1132:1133:1134"]},"author_link":["68898","68892","758","68893","68899","68894","68895","22643","68896","68897","68891","99"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-04-15","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"255","bibliographicPageStart":"248","bibliographicVolumeNumber":"550","bibliographic_titles":[{"bibliographic_title":"Science of the Total Environment"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study aims to evaluate the endocrine-disrupting effect of dioxin congeners on adrenal steroid hormones in mother-child pairs. In our previous study, we found that cortisol and cortisone levels were higher in the blood and the saliva of mothers living in a dioxin hotspot area than in mothers from a non-exposed region in Vietnam. In this follow-up study, we determined the salivary steroid hormone levels in 49 and 55 three-year-old children of these mothers in the hotspot and non-exposed region, respectively. Steroid hormones were determined by liquid chromatography-tandem mass spectrometry, and dioxin in the maternal breast milk was determined by gas chromatography-mass spectrometry. Dioxin levels in the breast milk of mothers from the hotspot (median total toxic equivalents polychlorinated dibenzodioxins/polychlorinated dibenzofurans; (TEQ PCDD/Fs) of 11. pg/g lipid) were three to four times higher than those of mothers in the non-exposed region (median TEQ PCDD/Fs of 3.07. pg/g lipid). Salivary dehydroepiandrosterone (DHEA) levels in children were found to be significantly lower in the hotspot than in the non-exposed region, while cortisol and cortisone levels were not different between the two regions. Highly chlorinated dioxin congeners, such as octacholorodibenzodioxin (OCDD), 1,2,3,4,6,7,8-heptacholorodibenzodioxin (HpCDD) and 1,2,3,4 (or 6), 7,8-hexachlorodibenzodioxin Hx(CDD), showed stronger inverse associations with the children's salivary DHEA than other lowly chlorinated dioxin congeners. Glucocorticoid levels in the mothers exhibited a significantly positive correlation with OCDD and HpCDD/F (polychlorinated dibenzofurans). In conclusion, highly chlorinated dioxin congeners are more strongly correlated with endocrine-disrupting effects on adrenal hormones, resulting in high cortisol levels in the mothers and low DHEA levels in their three-year-old children. © 2016 Elsevier B.V.","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Embargo Period 24 months","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.scitotenv.2016.01.025","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.elsevier.com/locate/issn/00489697","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © Elsevier B.V. (CC-BY NC ND)"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00836666","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0048-9697","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kido, Teruhiko"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Honma, Seijiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nhu, Dang Duc"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Manh, Ho Dung"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tung, Dao Van"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Liang, Sun Xian"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Anh, Le Thai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okamoto, Rie"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Maruzeni, Shoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakagawa, Hideaki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Hung, Nguyen Ngoc"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Son, Le Ke"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-16"}],"displaytype":"detail","filename":"ME-PR-KIDO-T-248.pdf","filesize":[{"value":"640.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-KIDO-T-248.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14189/files/ME-PR-KIDO-T-248.pdf"},"version_id":"bebe6c3a-cbf2-44c0-b090-0e1021abdef7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inverse association of highly chlorinated dioxin congeners in maternal breast milk with dehydroepiandrosterone levels in three-year-old Vietnamese children","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inverse association of highly chlorinated dioxin congeners in maternal breast milk with dehydroepiandrosterone levels in three-year-old Vietnamese children"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-05"},"publish_date":"2017-12-05","publish_status":"0","recid":"14189","relation_version_is_last":true,"title":["Inverse association of highly chlorinated dioxin congeners in maternal breast milk with dehydroepiandrosterone levels in three-year-old Vietnamese children"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T17:47:10.455027+00:00"}