{"created":"2023-07-27T06:29:24.771423+00:00","id":14203,"links":{},"metadata":{"_buckets":{"deposit":"ed468991-3c06-41d0-9414-46b5fa216c77"},"_deposit":{"created_by":3,"id":"14203","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14203"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014203","sets":["1132:1133:1134"]},"author_link":["24370","373","622","684","21810","24372","688","22572","666","23772","1196","569","310","22393","22001","23775","24371","92","508"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"1124","bibliographicPageStart":"1119","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"Experimental and Therapeutic Medicine"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Sinusoidal obstruction syndrome (SOS), previously known as veno-occlusive disease, is relatively rare subsequent to liver transplantation (LT). SOS refractory to medical therapy, however, can result in centrilobular fibrosis, portal hypertension and liver failure. Although sinusoidal endothelial cell damage around central venules (zone 3) occurs early in the development of SOS, the detailed mechanism of SOS development and its association with thrombocytopenia are not yet completely understood. The present report describes a patient who experienced SOS with unexplained thrombocytopenia following living donor LT. The progression of SOS resulted in graft dysfunction and the patient succumbed. The presence of platelets in the liver allograft was assayed immunohistochemically using antibody to the platelet marker cluster of differentiation 42b (platelet glycoprotein Ib). Platelet aggregates were found attached to hepatocytes along the sinusoid and within the cytoplasm of hepatocytes, particularly in zone 3. By contrast, no staining was observed in zone 1. These findings suggested that extravasated platelet aggregation in the space of Disse and the phagocytosis of platelets by hepatocytes were initiated by sinusoidal endothelial cell damage due to the toxicity of the immunosuppressant tacrolimus or a corticosteroid pulse, and that platelet activation and degranulation may be at least partially involved in the mechanism responsible for SOS.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3892/etm.2015.2245","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA12610820","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1792-0981","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakanuma, Shinichi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Miyashita, Tomoharu"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Hayashi, Hironori"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Tajima, Hidehiro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Takamura, Hiroyuki"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Tsukada, Tomoya"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Okamoto, Koichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Sakai, Seisho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Makino, Isamu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kinoshita, Jun"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Nakamura, Keishi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Oyama, Katsunobu"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Inokuchi, Masafumi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Nakagawara, Hisatoshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Ninomiya, Itasu"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Kitagawa, Hirohisa"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Fushida, Sachio"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Fujimura, Takashi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ohta, Tetsuo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-NAKANUMA-S-1119.pdf","filesize":[{"value":"535.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-NAKANUMA-S-1119.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14203/files/ME-PR-NAKANUMA-S-1119.pdf"},"version_id":"7d805ae4-8802-4a9d-a1c3-a308bc217cc7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Extravasated platelet aggregation in liver zone 3 may correlate with the progression of sinusoidal obstruction syndrome following living donor liver transplantation: A case report","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Extravasated platelet aggregation in liver zone 3 may correlate with the progression of sinusoidal obstruction syndrome following living donor liver transplantation: A case report"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14203","relation_version_is_last":true,"title":["Extravasated platelet aggregation in liver zone 3 may correlate with the progression of sinusoidal obstruction syndrome following living donor liver transplantation: A case report"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:51:15.083317+00:00"}