@article{oai:kanazawa-u.repo.nii.ac.jp:00014252,
 author = {酒井, 克也 and 西内, 巧 and 今村, 龍 and 佐藤, 拓輝 and 松本, 邦夫 and Adachi, Eri and Sakai, Katsuya and Nishiuchi, Takumi and Imamura, Ryu and Sato, Hiroki and Matsumoto, Kunio},
 issue = {43},
 journal = {Oncotarget},
 month = {Sep},
 note = {A dynamic phenotypic change contributes to the metastatic progression and drug resistance in malignant melanoma. Nevertheless, mechanisms for a phenotypic change have remained to be addressed. Here, we show that Met receptor expression changes in a cell-autonomous manner and can distinguish phenotypical differences in growth, as well as in metastatic and drug-resistant characteristics. In metastatic melanoma, the cells are composed of Met-low and Met-high populations. Met-low populations have stem-like gene expression profiles, are resistant to chemotherapeutic agents, and have shown abundant angiogenesis and rapid tumor growth in subcutaneous inoculation. Met-high populations have a differentiated phenotype, are relatively resistant to B-RAF inhibitor, and are highly metastatic to the lungs. Met plays a definitive role in lung metastasis because the lung metastasis of Met-high cells requires Met, and treatment of mice with the Met-containing exosomes from Met-high cells facilitates lung metastasis by Met-low cells. Clonal cell fate analysis showed the hierarchical phenotypical changes from Met-low to Met-high populations. Met-low cells either showed self-renewal or changed into Met-high cells, whereas Met-high cells remained Met-high. Clonal transition from Met-low to Met-high cells accompanied changes in the gene expression profile, in tumor growth, and in metastasis that were similar to those in Met-high cells. These findings indicate that malignant melanoma has the ability to undergo phenotypic change by a cell-intrinsic/autonomous mechanism that can be characterized by Met expression., 金沢大学ナノ生命科学研究所 / 金沢大学がん進展制御研究所},
 pages = {70779--70793},
 title = {Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma},
 volume = {7},
 year = {2016}
}