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Nevertheless, mechanisms for a phenotypic change have remained to be addressed. Here, we show that Met receptor expression changes in a cell-autonomous manner and can distinguish phenotypical differences in growth, as well as in metastatic and drug-resistant characteristics. In metastatic melanoma, the cells are composed of Met-low and Met-high populations. Met-low populations have stem-like gene expression profiles, are resistant to chemotherapeutic agents, and have shown abundant angiogenesis and rapid tumor growth in subcutaneous inoculation. Met-high populations have a differentiated phenotype, are relatively resistant to B-RAF inhibitor, and are highly metastatic to the lungs. Met plays a definitive role in lung metastasis because the lung metastasis of Met-high cells requires Met, and treatment of mice with the Met-containing exosomes from Met-high cells facilitates lung metastasis by Met-low cells. Clonal cell fate analysis showed the hierarchical phenotypical changes from Met-low to Met-high populations. Met-low cells either showed self-renewal or changed into Met-high cells, whereas Met-high cells remained Met-high. Clonal transition from Met-low to Met-high cells accompanied changes in the gene expression profile, in tumor growth, and in metastasis that were similar to those in Met-high cells. These findings indicate that malignant melanoma has the ability to undergo phenotypic change by a cell-intrinsic/autonomous mechanism that can be characterized by Met expression.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学ナノ生命科学研究所 / 金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00014239","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Impact Journals"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.18632/oncotarget.12221","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.impactjournals.com/oncotarget/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2017 Impact Journals"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Adachi, Eri"}],"nameIdentifiers":[{"nameIdentifier":"47536","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakai, Katsuya"}],"nameIdentifiers":[{"nameIdentifier":"88142","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10523318","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10523318"}]},{"creatorNames":[{"creatorName":"Nishiuchi, Takumi"}],"nameIdentifiers":[{"nameIdentifier":"79940","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20334790","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20334790"}]},{"creatorNames":[{"creatorName":"Imamura, Ryu"}],"nameIdentifiers":[{"nameIdentifier":"71982","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10311680","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10311680"}]},{"creatorNames":[{"creatorName":"Sato, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"88146","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20781173","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20781173"}]},{"creatorNames":[{"creatorName":"Matsumoto, Kunio"}],"nameIdentifiers":[{"nameIdentifier":"86390","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90201780","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90201780"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-MATSUMOTO-K-70779.pdf","filesize":[{"value":"7.3 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MATSUMOTO-K-70779.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14252/files/ME-PR-MATSUMOTO-K-70779.pdf"},"version_id":"a7725bdb-dd94-492b-9953-7c601853c8c3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma"}]},"item_type_id":"4","owner":"3","path":["3021"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14252","relation_version_is_last":true,"title":["Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2024-06-25T05:31:27.646042+00:00"}