@article{oai:kanazawa-u.repo.nii.ac.jp:00014264, author = {Mori, Taiki and Murasawa, Yusuke and Ikai, Rina and Hayakawa, Tomoko and Nakamura, Hiroyuki and Ogiso, Noboru and Niida, Shumpei and Watanabe, Ken}, issue = {4}, journal = {Experimental Animals}, month = {Jan}, note = {IL-6 is a cytokine that is involved in various physiological and pathological conditions, and approaches using gain-of-function transgenic animals have contributed in elucidating IL-6 function. However, studies of the multiple functions of IL-6 in vivo are very time consuming because they require the generation of transgenic mice that harbor the gene encoding IL-6 under the control of specific promoters to mimic different pathologies. Here, we report the establishment of a conditional human IL-6 transgenic mouse, LGL-IL6, which conditionally expresses human IL-6 by taking advantage of the well-characterized Cre recombinase drivers.}, pages = {455--463}, title = {Generation of a transgenic mouse line for conditional expression of human IL-6}, volume = {65}, year = {2016} }