{"created":"2023-07-27T06:29:29.236666+00:00","id":14272,"links":{},"metadata":{"_buckets":{"deposit":"9d7745fd-61f1-4e4e-a193-125e7865bee0"},"_deposit":{"created_by":3,"id":"14272","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14272"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014272","sets":["1132:1133:1134"]},"author_link":["24579","23652","23626","80143","20563"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1938","bibliographicPageStart":"1930","bibliographicVolumeNumber":"89","bibliographic_titles":[{"bibliographic_title":"日本泌尿器科学会雑誌 = The Japanese Journal of Urology"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kunimi, Kazuto"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Uchibayashi, Tadao"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Hisazumi, Haruo"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"手術的に得られた腎癌24例, 前立腺癌18例, 腎孟移行上皮癌11例に制限酵素切断多型性 (RFLP) 分析を施行し, 各種癌遺伝子の増幅, あるいは癌抑制遺伝子の不活化の有無につき検討した. Harvey ras, c-myc, c-fos, c-myb, EGFR, PDGFRいずれの癌遺伝子も各腫瘍型にてDNAコピー数の過剰増加を呈さなかった. 一方, RFLP分析にて癌抑制遺伝子の不活化を示す染色体座位欠失所見が各腫瘍型で検出された. 腎癌では, 第3染色体短腕 (3p) に68%, 第18染色体長腕 (18q) に33%, Y染色体に29%, 17pに27%の順に高頻度に座位欠失が見られた. 前立腺癌では, 16q (67%), 8p (50%), 18q (43%) 10p (40%), 10q (38%) に, 腎孟移行上皮癌では, 17p (73%), 11p (64%), 9p (40%) に高頻度の座位に欠失が認められた. 各腫瘍型において癌細胞の悪性度が高い症例ほど多数の座位欠失を伴う傾向を示した. We applied restriction fragment length polymorphism (RFLP) analysis to 24 cases of renal cell carcinomas (RCC), 18 cases of prostate adenocarcinomas (PC), and 11 cases of transitional cell carcinomas (TCC) in the renal pelvis to study the oncogene amplification and inactivation of tumor suppressor genes. All of the cases showed no amplification nor gross rearrangements of the Harvey ras, c-myc, c-fos, c-myb, EGFR and PDGFR. In contrast, RFLP analyses demonstrated allelic losses interpreted as inactivational events of TSGs among the tumor forms studied. RCC had allelic losses on the short arm of chromosome 3 (3p) (68%), the long arm of chromosome 18 (18q) (33%), Y chromosome (29%), and 17p (27%) at high frequencies. PC showed frequent allelic losses on 16q (67%), 8p (50%), 18q (43%), lop (40%), and 10q (38%). TCC had allelic losses on 17p (73%), 11p (64%), and 9p (40%). It was likely that the cases with the more malignant grade tumor had the more allelic losses.","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出版者照会後に全文公開 / 許可を得て公開","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00014259","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本泌尿器科学会 Japanese Urological Association"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.5980/jpnjurol1989.82.1930","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.urol.or.jp/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/browse/jpnjurol/-char/ja/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © Japanese Urological Association"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00196577","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-5287","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"國見, 一人"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"打林, 忠雄"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"久住, 治男"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-10-26"}],"displaytype":"detail","filename":"ME-PR-HISAZUMI-H-1930.pdf","filesize":[{"value":"8.0 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HISAZUMI-H-1930.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14272/files/ME-PR-HISAZUMI-H-1930.pdf"},"version_id":"3e6f7137-fea6-4356-8d50-cb74bb5ec88f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"泌尿器科悪性腫瘍における癌遺伝子増幅と癌抑制遺伝子の不活化: 制限酵素切断多型性分析による検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"泌尿器科悪性腫瘍における癌遺伝子増幅と癌抑制遺伝子の不活化: 制限酵素切断多型性分析による検討"},{"subitem_title":"Oncogene Amplification and Inactivation of Tumor Suppressor Genes in Urological Malignant Tumors: The Application of Restriction Fragment Length Polymorphism Analysis","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-10-26"},"publish_date":"2018-10-26","publish_status":"0","recid":"14272","relation_version_is_last":true,"title":["泌尿器科悪性腫瘍における癌遺伝子増幅と癌抑制遺伝子の不活化: 制限酵素切断多型性分析による検討"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T16:54:03.330370+00:00"}