{"created":"2023-07-27T06:29:29.303521+00:00","id":14273,"links":{},"metadata":{"_buckets":{"deposit":"0dc885a9-2d15-449e-9e7d-96e08d39c7d5"},"_deposit":{"created_by":3,"id":"14273","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14273"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014273","sets":["1132:1133:1134"]},"author_link":["24584","24582","413","24586","568","62","24583","24585","92"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-11-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"17192","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hepatic insulin resistance and nonalcoholic steatohepatitis (NASH) could be caused by excessive hepatic lipid accumulation and peroxidation. Vitamin E has become a standard treatment for NASH. However, astaxanthin, an antioxidant carotenoid, inhibits lipid peroxidation more potently than Vitamin E. Here, we compared the effects of astaxanthin and Vitamin E in NASH. We first demonstrated that astaxanthin ameliorated hepatic steatosis in both genetically (ob/ob) and high-fat-diet-induced obese mice. In a lipotoxic model of NASH: mice fed a high-cholesterol and high-fat diet, astaxanthin alleviated excessive hepatic lipid accumulation and peroxidation, increased the proportion of M1-type macrophages/Kupffer cells, and activated stellate cells to improve hepatic inflammation and fibrosis. Moreover, astaxanthin caused an M2-dominant shift in macrophages/Kupffer cells and a subsequent reduction in CD4+ and CD8+ T cell recruitment in the liver, which contributed to improved insulin resistance and hepatic inflammation. Importantly, astaxanthin reversed insulin resistance, as well as hepatic inflammation and fibrosis, in pre-existing NASH. Overall, astaxanthin was more effective at both preventing and treating NASH compared with Vitamin E in mice. Furthermore, astaxanthin improved hepatic steatosis and tended to ameliorate the progression of NASH in biopsy-proven human subjects. These results suggest that astaxanthin might be a novel and promising treatment for NASH.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/srep17192","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ni, Yinhua"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagashimada, Mayumi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Zhuge, Fen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zhan, Lili"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagata, Naoto"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Tsutsui, Akemi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakanuma, Yasuni"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Kaneko, Shuichi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Ota, Tsuguhito"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-OTA-T-17192.pdf","filesize":[{"value":"3.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-OTA-T-17192.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14273/files/ME-PR-OTA-T-17192.pdf"},"version_id":"0dc93aa9-850f-4e66-bf59-419c27d48ac7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with Vitamin E","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with Vitamin E"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14273","relation_version_is_last":true,"title":["Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with Vitamin E"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:50:18.788859+00:00"}