@article{oai:kanazawa-u.repo.nii.ac.jp:00014275,
 author = {大貝, 和裕 and 杉谷, 加代 and 郡山, 恵樹 and 加藤, 聖 and Ogai, Kazuhiro and Hisano, Suguru and Sugitani, Kayo and Koriyama, Yoshiki and Kato, Satoru},
 journal = {Advances in Experimental Medicine and Biology},
 month = {Oct},
 note = {Zebrafish can regenerate several organs such as the tail fin, heart, central nervous system, and photoreceptors. Very recently, a study has demonstrated the photoreceptor regeneration in the alkylating agent N-methyl-N-nitrosourea (MNU)- induced retinal degeneration (RD) zebrafish model, in which whole photoreceptors are lost within a week after MNU treatment and then regenerated within a month. The research has also shown massive proliferation of Müller cells within a week. To address the question of whether proliferating Müller cells are the source of regenerating photoreceptors, which remains unknown in the MNU-induced zebrafish RD model, we employed a BrdU pulse-chase technique to label the proliferating cells within a week after MNU treatment. As a result of the BrdU pulse-chase technique, a number of BrdU+ cells were observed in the outer nuclear layer as well as the inner nuclear layer. This implies that regenerating photoreceptors are derived from proliferating Müller cells in the zebrafish MNU-induced RD model. © Springer International Publishing Switzerland 2016., [Book Chapter]},
 pages = {685--692},
 title = {Cell fate of müller cells during photoreceptor regeneration in an N-methyl-N-nitrosourea- induced retinal degeneration model of zebrafish},
 volume = {854},
 year = {2016}
}