{"created":"2023-07-27T06:29:29.431666+00:00","id":14275,"links":{},"metadata":{"_buckets":{"deposit":"b584f637-55fe-4ec7-8573-aac038f2729c"},"_deposit":{"created_by":3,"id":"14275","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14275"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014275","sets":["4281:4291:4312"]},"author_link":["24590","72","371","2865","332","23291"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-10-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"692","bibliographicPageStart":"685","bibliographicVolumeNumber":"854","bibliographic_titles":[{"bibliographic_title":"Advances in Experimental Medicine and Biology"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大貝, 和裕"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"杉谷, 加代"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"郡山, 恵樹"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"加藤, 聖"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Zebrafish can regenerate several organs such as the tail fin, heart, central nervous system, and photoreceptors. Very recently, a study has demonstrated the photoreceptor regeneration in the alkylating agent N-methyl-N-nitrosourea (MNU)- induced retinal degeneration (RD) zebrafish model, in which whole photoreceptors are lost within a week after MNU treatment and then regenerated within a month. The research has also shown massive proliferation of Müller cells within a week. To address the question of whether proliferating Müller cells are the source of regenerating photoreceptors, which remains unknown in the MNU-induced zebrafish RD model, we employed a BrdU pulse-chase technique to label the proliferating cells within a week after MNU treatment. As a result of the BrdU pulse-chase technique, a number of BrdU+ cells were observed in the outer nuclear layer as well as the inner nuclear layer. This implies that regenerating photoreceptors are derived from proliferating Müller cells in the zebrafish MNU-induced RD model. © Springer International Publishing Switzerland 2016.","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"[Book Chapter]","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00014262","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/978-3-319-17121-0_91","subitem_relation_type_select":"DOI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"The final publication is available at www.springerlink.com/article/chapter/10.1007%2F978-3-319-17121-0_91"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00512642","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0065-2598","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ogai, Kazuhiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Hisano, Suguru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugitani, Kayo"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Koriyama, Yoshiki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Kato, Satoru"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-OOGAI-K-685.pdf","filesize":[{"value":"363.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-OOGAI-K-685.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14275/files/ME-PR-OOGAI-K-685.pdf"},"version_id":"6714e96a-ee32-4d78-b756-bb69e04916f7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cell fate of müller cells during photoreceptor regeneration in an N-methyl-N-nitrosourea- induced retinal degeneration model of zebrafish","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cell fate of müller cells during photoreceptor regeneration in an N-methyl-N-nitrosourea- induced retinal degeneration model of zebrafish"}]},"item_type_id":"4","owner":"3","path":["4312"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14275","relation_version_is_last":true,"title":["Cell fate of müller cells during photoreceptor regeneration in an N-methyl-N-nitrosourea- induced retinal degeneration model of zebrafish"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T08:49:00.039152+00:00"}