{"created":"2023-07-27T06:29:30.722242+00:00","id":14295,"links":{},"metadata":{"_buckets":{"deposit":"e151e409-c218-4173-930b-cabcb14932f1"},"_deposit":{"created_by":3,"id":"14295","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14295"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014295","sets":["1132:1133:1134"]},"author_link":["24649","24646","24647","24652","24650","24645","24651","255","22034","24653","24648"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-08-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageStart":"e0137140","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"PLoS ONE"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: Disease progression varies among HIV-1-infected individuals. The present study aimed to explore possible viral and host factors affecting disease progression in HIV-1-infected children. Methods: Since 2000, 102 HIV-1 vertically-infected children have been followed-up in Kenya. Here we studied 29 children (15 male/14 female) who started antiretroviral treatment at <5 years of age (rapid progressors; RP), and 32 (17 male/15 female) who started at >10 years of age (slow progressors; SP). Sequence variations in the HIV-1 gag and nef genes and the HLA class I-related epitopes were compared between the two groups. Results: Based on nef sequences, HIV-1 subtypes A1/D were detected in 62.5%/12.5% of RP and 66.7%/20%of SP, with no significant difference in subtype distribution between groups (p = 0.8). In the ten Nef functional domains, only the PxxP3 region showed significantly greater variation in RP (33.3%) than SP (7.7%, p = 0.048). Gag sequences did not significantly differ between groups. The reportedly protective HLA-A alleles, A∗74:01, A∗32:01 and A∗26, were more commonly observed in SP (50.0%) than RP (11.1%, p = 0.010), whereas the reportedly disease-susceptible HLA-B∗45:01 was more common in RP (33.3%) than SP (7.4%, p = 0.045). Compared to RP, SP showed a significantly higher median number of predicted HLA-B-related 12-mer epitopes in Nef (3 vs. 2, p = 0.037), HLA-B-related 11-mer epitopes in Gag (2 vs. 1, p = 0.029), and HLA-A-related 9-mer epitopes in Gag (4 vs. 1, p = 0.051). SP also had fewer HLA-C-related epitopes in Nef (median 4 vs. 5, p = 0.046) and HLA-C-related 11-mer epitopes in Gag (median 1 vs. 1.5, p = 0.044) than RP. Conclusions: Compared to rapid progressors, slow progressors had more protective HLA-A alleles and more HLA-B-related epitopes in both the Nef and Gag proteins. These results suggest that the host factor HLA plays a stronger role in disease progression than the Nef and Gag sequence variations in HIV-1-infected Kenyan children. © 2015 Saina et al.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0137140","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Saina, Matilda"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bi, Xiuqiong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Lihana, Raphael"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Lwembe, Raphael"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishizaki, Azumi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Panikulam, Annie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Palakudy, Tresa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Musoke, Rachel"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Owens, Mary"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Songok, Elijah Maritim"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ichimura, Hiroshi"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-ICHIMURA-H-0137140.pdf","filesize":[{"value":"418.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-ICHIMURA-H-0137140.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14295/files/ME-PR-ICHIMURA-H-0137140.pdf"},"version_id":"894cf056-4133-495b-802f-e321f89f7a7d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Comparison of HIV-1 nef and gag variations and host HLA characteristics as determinants of disease progression among HIV-1 vertically infected Kenyan children","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparison of HIV-1 nef and gag variations and host HLA characteristics as determinants of disease progression among HIV-1 vertically infected Kenyan children"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14295","relation_version_is_last":true,"title":["Comparison of HIV-1 nef and gag variations and host HLA characteristics as determinants of disease progression among HIV-1 vertically infected Kenyan children"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:49:57.642627+00:00"}