@article{oai:kanazawa-u.repo.nii.ac.jp:00014331, author = {Mukai, Kanae and Koike, Miki and Nakamura, Saki and Kawaguchi, Yuka and Katagiri, Fumika and Nojiri, Saki and Yamada, Yuki and Miyajima, Eri and Matsumoto, Mayuko and Komatsu, Emi and Nakajima, Yukari and Urai, Tamae and Murakado, Naoko and Nakatani, Toshio}, issue = {2015}, journal = {Evidence-based Complementary and Alternative Medicine}, month = {Jan}, note = {The aim of this study was to evaluate the effect of the combined use of Japanese honey and hydrocolloid dressing (HCD) on cutaneous wound healing. Mice were divided into four groups: the Acacia (Japan) + HCD, Manuka (New Zealand) + HCD, Chinese milk vetch (Japan) + HCD, and HCD (control) groups. The mice received two full-thickness wounds. The wounds of the HCD group were covered with HCD, whereas those of the other groups were treated with 0.1 mL of the relevant type of honey, before being covered with HCD. Wound area was significantly smaller in the HCD group than in the Acacia + HCD and Manuka + HCD groups on day 13 and days 8-14, respectively. Moreover, compared with the HCD group, reepithelialization was delayed in the Acacia + HCD group and reepithelialization and collagen deposition were delayed in the Chinese milk vetch + HCD and Manuka + HCD groups. These results indicate that the combined use of Japanese honey and HCD does not promote cutaneous wound healing compared with the use of HCD alone. Thus, this method is probably not useful for promoting healing. © 2015 Kanae Mukai et al.}, title = {Evaluation of the effects of a combination of Japanese honey and hydrocolloid dressing on cutaneous wound healing in male mice}, year = {2015} }