@article{oai:kanazawa-u.repo.nii.ac.jp:00014352,
 author = {Takazakura, Akiko and Sakurai, Masaru and Bando, Yukihiro and Misu, Hirofumi and Takeshita, Yumie and Kita, Yuki and Shimizu, Akiko and Hayakawa, Tetsuo and Kato, Ken-ichiro and Kaneko, Shuichi and Takamura, Toshinari},
 issue = {3},
 journal = {Journal of Diabetes Investigation},
 month = {May},
 note = {Introduction: Several studies have shown that statins suppress the progression of diabetic nephropathy. However, few reports have directly compared the renoprotective effects between potent and conventional statins. Materials and Methods: Patients with diabetic nephropathy, selected as those with a serum creatinine level of 0.9-1.5 mg/dL and simultaneously having either microalbuminuria or positive proteinuria, were randomly assigned to one of three groups: a conventional diet therapy group, a group given 10 mg of pravastatin and a group given 10 mg of atorvastatin. Renal function was evaluated before and after a 12-month period of therapy. Results: The atorvastatin group had a significant decrease in low-density lipoprotein cholesterol at 3 months and thereafter compared with the other groups. The urinary albumin-to-creatinine ratio significantly decreased in the atorvastatin group; the degree of this decrease was significantly greater than that in the diet therapy group. The kidney function estimated with cystatin C (CysC) and the estimated glomerular filtration rate calculated from CysC were significantly preserved in the atorvastatin group compared with the pravastatin group. In a multivariate regression analysis, the use of atorvastatin was the only explanatory variable for the changes in CysC; this was independent of changes in low-density lipoprotein cholesterol. Conclusions: Atorvastatin is more effective than pravastatin for the prevention of increase in CysC, and this renoprotective effect was considered to a result of the pleiotropic effect of atorvastatin independent of its lipid-lowering effect. This study was registered with UMIN (no. UMIN 000001774). © 2014 The Authors.},
 pages = {346--353},
 title = {Renoprotective effects of atorvastatin compared with pravastatin on progression of early diabetic nephropathy},
 volume = {6},
 year = {2015}
}