@article{oai:kanazawa-u.repo.nii.ac.jp:00014358,
 author = {Kinuya, Seigo and Li, Xiao-Feng and Yokoyama, Kunihiko and Mori, Hirofumi and Shiba, Kazuhiro and Watanabe, Naoto and Shuke, Noriyuki and Bunko, Hisashi and Michigishi, Takatoshi and Tonami, Norihisa},
 issue = {7},
 journal = {Cancer Science},
 month = {Jul},
 note = {Peritoneal spread is one of major causes of mortality in colorectal cancer patients. In the current investigation, the efficacy of radio-immunotherapy (RIT) with i.p. administration of an anti-colorectal cancer IgG1, 131 I-A7, was compared to that with i.v. administration in BALB/c female mice bearing peritoneal nodules of LS180 human colon cancer cells, at the same toxicity level. Distribution of either i.p. or i.v. administered 131 I-A7 and i.p. administered irrelevant 131 I-HPMS-1 was assessed. Based on the results of toxicity determination at increments of 2 MBq and estimated dosimetry, an i.p. dose of 11 MBq and an i.v. dose of 9 MBq were chosen for treatment. Mice were monitored for long-term survival: untreated mice (n=11), mice undergoing i.p. RIT with 131 I-A7 (n=11), mice undergoing i.v. RIT with 131 I-A7 (n=11) and mice undergoing non-specific i.p. RIT with 131 I-HPMS-1 (n=5). Intraperitoneal injection of 131 I-A7 produced faster and greater tumor accumulation than i.v. injection: 34.2±16.5% of the injected dose per g (% ID/ g) and 11.1±3.6% ID/g at 2 h, respectively (P<0.0001). Consequently, cumulative radioactivity in tumors was 1.73-fold higher with i.p. injection. 131 I-HPMS-1 did not show specific accumulation. Non-specific RIT with 131 I-HPMS-1 (mean survival, 26.0±2.5 days) did not affect the survival as compared to no treatment (26.7±1.9 days). Intravenous RIT with 131 I-A7 prolonged the survival of mice to 32.8±1.8 days (P<0.01). Intraperitoneal RIT with 131 I-A7 improved the survival more significantly and attained cure in 2 of 11 mice (P<0.05 vs. i.v. RIT). In conclusion, i.p. RIT is more beneficial in treating peritoneal carcinomatosis of colon cancer than i.v. RIT in a murine model., 医薬保健研究域医学系},
 pages = {650--654},
 title = {Intraperitoneal radioimmunotherapy in treating peritoneal carcinomatosis of colon cancer in mice compared with systemic radioimmunotherapy},
 volume = {94},
 year = {2003}
}