{"created":"2023-07-27T06:29:35.199625+00:00","id":14364,"links":{},"metadata":{"_buckets":{"deposit":"65a8418c-dbf2-4d86-856c-e92182ac87ee"},"_deposit":{"created_by":3,"id":"14364","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14364"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014364","sets":["1132:1133:1134"]},"author_link":["9709","24865","441","284","24868","24867","297","24866","1191"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"242","bibliographicPageStart":"237","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"OncoTargets and Therapy"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The effects of inductive hyperthermia on lung cancer have yet to be fully investigated. Magnetic nanoparticles used in inductive hyperthermia are made-to-order and expensive. This study was performed to investigate the use of ferucarbotran in inductive hyperthermia and to clarify whether inductive hyperthermia using ferucarbotran promotes antitumor effects in vivo using a lung cancer cell line. Methods: We injected A549 cells subcutaneously into the right thighs of BALB/c nu/nu nude mice. Forty mice with A549 xenografts were then classified into three groups. Group 1 was the control group. All mice in groups 2 and 3 had ferucarbotran injected into their tumors, and mice in group 3 were then subjected to alternating magnetic field irradiation. We evaluated tumor temperature during the hyperthermic procedure, the time course of tumor growth, histologic findings in tumors after hyperthermic treatment, and adverse events. Results: Intratumor temperature rose rapidly and was maintained at 43°C-45°C for 20 minutes in an alternating magnetic field. Tumor volumes in groups 1 and 2 increased exponentially, but tumor growth in group 3 was significantly suppressed. No severe adverse events were observed. Histologic findings for the tumors in group 3 revealed mainly necrosis. Conclusion: Inductive hyperthermia using ferucarbotran is a beneficial and promising approach in the treatment of lung cancer. Ferucarbotran is a novel tool for further development of inductive hyperthermia. © 2013 Araya et al, publisher and licensee Dove Medical Press Ltd.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Dove Medical Press Ltd."}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2147/OTT.S42815","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1178-6930","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Araya, Tomoyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kasahara, Kazuo"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Nishikawa, Shingo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kimura, Hideharu"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Sone, Takashi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Nagae, Hideo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikehata, Yoshio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagano, Isamu"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Fujimura, Masaki"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-KASAHARA-K-237.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-KASAHARA-K-237.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14364/files/ME-PR-KASAHARA-K-237.pdf"},"version_id":"3b8212df-eac4-450c-af55-ab4969658ce4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Antitumor effects of inductive hyperthermia using magnetic ferucarbotran nanoparticles on human lung cancer xenografts in nude mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antitumor effects of inductive hyperthermia using magnetic ferucarbotran nanoparticles on human lung cancer xenografts in nude mice"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14364","relation_version_is_last":true,"title":["Antitumor effects of inductive hyperthermia using magnetic ferucarbotran nanoparticles on human lung cancer xenografts in nude mice"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:48:31.383260+00:00"}