{"created":"2023-07-27T06:29:37.323542+00:00","id":14397,"links":{},"metadata":{"_buckets":{"deposit":"c8305360-c603-4c77-8f96-e15e52d30cee"},"_deposit":{"created_by":3,"id":"14397","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14397"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014397","sets":["4281:4291:4312"]},"author_link":["24993","24994","24995","24992","2865","24996","32","24991","24398"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"469","bibliographicPageStart":"462","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"International Journal of Cosmetic Science"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大貝, 和裕"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"須釜, 淳子"}],"nameIdentifiers":[{},{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: A state of chronic inflammation, characterized by an increased level of tumour necrosis factor-alpha (TNF-α), is often found in the obese population. The negative effects of elevated TNF-α are not limited to systemic metabolism. It also reportedly affects skin integrity. Recently, the relationship between obesity and skin fragility was reported; however, there has been little insight into how the level of TNF-α in the skin in situ is related to the severity of obesity. In this study, we aimed to measure the level of TNF-α on the skin and to find the relationship between obesity and the level of TNF-α detected on the skin. Methods: We used a novel, non-invasive method called quantitative skin blotting. Fifty-nine healthy (but some were classified as being overweight or obese) Japanese males were enrolled as subjects. The levels of TNF-α detected on the abdominal and thigh skin along with the body composition were measured, followed by a correlation analysis. Results: Significant positive correlations were found between the levels of TNF-α detected on the skin and the severity of obesity such as body mass index (BMI), body fat weight and visceral fat rating. Conclusion: We found that high levels of TNF-α were detected on the skin of Japanese obese males, which implied the higher TNF-α in the skin. The elevation of skin TNF-α may be one factor related to skin fragility that is often found in obese individuals. © 2016 John Wiley & Sons Ltd.","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Embargo Period 12 months","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00014384","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Blackwell Publishing Ltd"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/ics.12312","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00234029","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0142-5463","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ogai, Kazuhiro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Matsumoto, M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aoki, M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Minematsu, Takeo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitamura, K."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sanada, H."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugama, Junko"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-OGAI-K-462.pdf","filesize":[{"value":"618.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-OGAI-K-462.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14397/files/ME-PR-OGAI-K-462.pdf"},"version_id":"a637ff4a-5636-4391-a26d-e95d3f62b9d0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Increased level of tumour necrosis factor-alpha (TNF-α) on the skin of Japanese obese males: Measured by quantitative skin blotting","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Increased level of tumour necrosis factor-alpha (TNF-α) on the skin of Japanese obese males: Measured by quantitative skin blotting"}]},"item_type_id":"4","owner":"3","path":["4312"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14397","relation_version_is_last":true,"title":["Increased level of tumour necrosis factor-alpha (TNF-α) on the skin of Japanese obese males: Measured by quantitative skin blotting"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T08:48:58.353547+00:00"}