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Sox11 balances dendritic morphogenesis with neuronal migration in the developing cerebral cortex
http://hdl.handle.net/2297/45897
http://hdl.handle.net/2297/458974998838a-afc4-4918-b0ef-165b1b1a9d1b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-KAWASAKI-H-5775.pdf (658.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Sox11 balances dendritic morphogenesis with neuronal migration in the developing cerebral cortex | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Hoshiba, Yoshio
× Hoshiba, Yoshio× Toda, Tomohisa× Ebisu, Haruka× Wakimoto, Mayu× Yanagi, Shigeru× Kawasaki, Hiroshi |
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| 書誌情報 |
Journal of Neuroscience 巻 36, 号 21, p. 5775-5784, 発行日 2016-05-25 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0270-6474 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10620404 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1523/JNEUROSCI.3250-15.2016 | |||||
| 出版者 | ||||||
| 出版者 | Society for Neuroscience | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The coordinated mechanisms balancing promotion and suppression of dendritic morphogenesis are crucial for the development of the cerebral cortex. Although previous studies have revealed important transcription factors that promote dendritic morphogenesis during development, those that suppress dendritic morphogenesis are still largely unknown. Here we found that the expression levels of the transcription factor Sox11 decreased dramatically during dendritic morphogenesis. Our loss- and gain-of-function studies using postnatal electroporation and in utero electroporation indicate that Sox11 is necessary and sufficient for inhibiting dendritic morphogenesis of excitatory neurons in the mouse cerebral cortex during development. Interestingly, we found that precocious suppression of Sox11 expression caused precocious branching of neurites and a neuronal migration defect. We also found that the end of radial migration induced the reduction of Sox11 expression. These findings indicate that suppression of dendritic morphogenesis by Sox11 during radial migration is crucial for the formation of the cerebral cortex. © 2016 the authors. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
