{"created":"2023-07-27T06:29:38.419507+00:00","id":14416,"links":{},"metadata":{"_buckets":{"deposit":"54c9b713-e651-495d-b03b-73e78798b800"},"_deposit":{"created_by":3,"id":"14416","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14416"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014416","sets":["1132:1133:1134"]},"author_link":["25086","25076","25082","25077","25081","294","25085","25080","255","22034","25084","25078","25079","25083"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-08-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageStart":"1245","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Sciences"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CD4+ T-lymphocyte destruction, microbial translocation, and systemic immune activation are the main mechanisms of the pathogenesis of human immunodeficiency virus type 1 (HIV) infection. To investigate the impact of HIV infection and antiretroviral therapy (ART) on the immune profile of and microbial translocation in HIV-infected children, 60 HIV vertically infected children (31 without ART: HIV(+) and 29 with ART: ART(+)) and 20 HIV-uninfected children (HIV(–)) aged 2–12 years were recruited in Vietnam, and their blood samples were immunologically and bacteriologically analyzed. Among the HIV(+) children, the total CD4+-cell and their subset (type 1 helper T-cell (Th1)/Th2/Th17) counts were inversely correlated with age (all p < 0.05), whereas regulatory T-cell (Treg) counts and CD4/CD8 ratios had become lower, and the CD38+HLA (human leukocyte antigen)-DR+CD8+- (activated CD8+) cell percentage and plasma soluble CD14 (sCD14, a monocyte activation marker) levels had become higher than those of HIV(–) children by the age of 2 years; the CD4/CD8 ratio was inversely correlated with the plasma HIV RNA load and CD8+-cell activation status. Among the ART(+) children, the total CD4+-cell and Th2/Th17/Treg-subset counts and the CD4/CD8 ratio gradually increased, with estimated ART periods of normalization being 4.8–8.3 years, whereas Th1 counts and the CD8+-cell activation status normalized within 1 year of ART initiation. sCD14 levels remained high even after ART initiation. The detection frequency of bacterial 16S/23S ribosomal DNA/RNA in blood did not differ between HIV-infected and -uninfected children. Thus, in children, HIV infection caused a rapid decrease in Treg counts and the early activation of CD8+ cells and monocytes, and ART induced rapid Th1 recovery and early CD8+-cell activation normalization but had little effect on monocyte activation. The CD4/CD8 ratio could therefore be an additional marker for ART monitoring. © 2016 by the authors; licensee MDPI, Basel, Switzerland.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI AG"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/ijms17081245","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1661-6596","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Bi, Xiuqiong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishizaki, Azumi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Nguyen, Lam Van"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda, Kazunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Pham, Hung Viet"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Phan, Chung Thi Thu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogata, Kiyohito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Giang, Thuy Thi Thanh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Phung, Thuy Thi Bich"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nguyen, Tuyen Thi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tokoro, Masaharu"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Pham, An Nhat"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Khu, Dung Thi Khanh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ichimura, Hiroshi"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-ICHIMURA-H-01245.pdf","filesize":[{"value":"941.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-ICHIMURA-H-01245.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14416/files/ME-PR-ICHIMURA-H-01245.pdf"},"version_id":"b718e645-f93d-457f-9e55-7ec16d6c918b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Impact of HIV infection and anti-retroviral therapy on the immune profile of and microbial translocation in HIV-infected children in Vietnam","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Impact of HIV infection and anti-retroviral therapy on the immune profile of and microbial translocation in HIV-infected children in Vietnam"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14416","relation_version_is_last":true,"title":["Impact of HIV infection and anti-retroviral therapy on the immune profile of and microbial translocation in HIV-infected children in Vietnam"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:47:44.423568+00:00"}