{"created":"2023-07-27T06:29:40.535484+00:00","id":14445,"links":{},"metadata":{"_buckets":{"deposit":"5c8c734c-d26b-4790-8cb7-7bb33e392cae"},"_deposit":{"created_by":3,"id":"14445","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14445"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014445","sets":["1132:1133:1134"]},"author_link":["25048","25247","25238","266","25246","25243","25242","25249","25244","25250","25239","25235","25240","22733","25248","25237","265","25241","25251","25236","21336","25245"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03-14","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"44312","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Alteration of the nuclear Ca2+ transient is an early event in cardiac remodeling. Regulation of the nuclear Ca2+ transient is partly independent of the cytosolic Ca2+ transient in cardiomyocytes. One nuclear membrane protein, emerin, is encoded by EMD, and an EMD mutation causes Emery-Dreifuss muscular dystrophy (EDMD). It remains unclear whether emerin is involved in nuclear Ca2+ homeostasis. The aim of this study is to elucidate the role of emerin in rat cardiomyocytes by means of hypertrophic stimuli and in EDMD induced pluripotent stem (iPS) cell-derived cardiomyocytes in terms of nuclear structure and the Ca2+ transient. The cardiac hypertrophic stimuli increased the nuclear area, decreased nuclear invagination, and increased the half-decay time of the nuclear Ca2+ transient in cardiomyocytes. Emd knockdown cardiomyocytes showed similar properties after hypertrophic stimuli. The EDMD-iPS cell-derived cardiomyocytes showed increased nuclear area, decreased nuclear invagination, and increased half-decay time of the nuclear Ca2+ transient. An autopsied heart from a patient with EDMD also showed increased nuclear area and decreased nuclear invagination. These data suggest that Emerin plays a crucial role in nuclear structure and in the nuclear Ca2+ transient. Thus, emerin and the nuclear Ca2+ transient are possible therapeutic targets in heart failure and EDMD. © The Author(s) 2017.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/srep44312","subitem_relation_type_select":"DOI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2017."}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimojima, Masaya"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yuasa, Shinsuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Motoda, Chikaaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yozu, Gakuto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagai, Toshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Shogo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Lachmann, Mark"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kashimura, Shin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takei, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kusumoto, Dai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kunitomi, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashiji, Nozomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Seki, Tomohisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tohyama, Shugo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashimoto, Hisayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kodaira, Masaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Egashira, Toru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Kenshi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Nakanishi, Chiaki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Sakata, Kenji"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yamagishi, Masakazu"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Fukuda, Keiichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-YAMAGISHI-M-44312.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-YAMAGISHI-M-44312.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14445/files/ME-PR-YAMAGISHI-M-44312.pdf"},"version_id":"46050908-ca93-4fac-802f-dfa23a55491d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient."}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14445","relation_version_is_last":true,"title":["Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient."],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:47:18.911869+00:00"}