@article{oai:kanazawa-u.repo.nii.ac.jp:00014469,
 author = {川尻, 剛照 and 野原, 淳 and 稲津, 明広 and 小林, 淳二 and 小泉, 順二 and 山岸, 正和 and 馬渕, 宏 and Nozue, Tsuyoshi and Kawashiri, Masa-aki and Higashikata, Toshinori and Nohara, Atsushi and Inazu, Akihiro and Kobayashi, Junji and Koizumi, Junji and Yamagishi, Masakazu and Mabuchi, Hiroshi},
 issue = {6},
 journal = {Journal of Atherosclerosis and Thrombosis},
 month = {Dec},
 note = {We retrospectively evaluated the frequency and identified the factors associated with the development of aortic stenosis (AS) in 96 patients with heterozygous familial hypercholesterolemia (FH). The frequency of AS was 31% (4/13) and that of critical stenosis was 15% (2/13) in older patients over the age of 70 years. All 4 patients with AS were female aged more than 70 years who were diagnosed with FH when aged more than 60 years. There were no significant differences in conventional coronary risk factors; however, the age at cardiac catheterization, age at diagnosis of FH and the cholesterol-years score (CYS) with AS were significantly higher than those without AS (p=0.006, p=0.017, p=0.021, respectively). In multiple regression analysis, CYS was a significant independent predictor for the development of AS (p=0.037) in 13 older patients over the age of 70 years. These results suggest that physicians should be aware that AS needs attention in older patients with heterozygous FH, especially women who have been diagnosed late in life and those who have been inadequately treated., 出版者照会後に全文公開},
 pages = {323--328},
 title = {Cholesterol-years score is associated with development of senile degenerative aortic stenosis in heterozygous familial hypercholesterolemia.},
 volume = {13},
 year = {2006}
}