{"created":"2023-07-27T06:29:45.833676+00:00","id":14527,"links":{},"metadata":{"_buckets":{"deposit":"079a303b-511a-4771-b90f-eef03a616438"},"_deposit":{"created_by":3,"id":"14527","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14527"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014527","sets":["1132:1133:1134"]},"author_link":["25541","25540","603","20083","1442","20086"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"36","bibliographicPageStart":"33","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"日本補完代替医療学会誌 = Japanese journal of complementary and alternative medicine"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】喫煙と発癌との因果関係は数多く報告されている．今回，我々は喫煙による有害作用として，活性酸素による DNA 酸化修飾物質であり発癌との因果関係も指摘されている 8-ヒドロキシデオキシグアノシン (8-OHdG) を指標に抗酸化成分による介入試験を行った． 【対象と方法】健康な喫煙者（男性 6 名，女性 6 名，平均年齢 38 歳，平均 Brinkmann 指数 264）を対象に行った．抗酸化成分として PICACE® (Pycnogenol® 15 mg/capsule, Vitamin E; 56.1 mg/capsule, Squalene; 138.9 mg/capsule) 4 カプセル/日を 14 日間服用し，服用前，服用後 3，7，14 日目，服用終了後 1 ヶ月目の尿中 8-OHdG を高速液体クロマトグラフィー (HPLC) 法で測定した． 【結果】服用 3 日目の尿中 8-OHdG は，クレアチニン換算値で 3.7±1.3 ng/mg CRE（平均±標準偏差）で，服用前の 5.0±2.0 ng/mg CRE より有意に低下していた (p<0.01)．服用終了後 1 ヶ月目の尿中 8-OHdG は，4.7±0.9 ng/mg CRE であり，投与中止によって再上昇した． 【結論】抗酸化成分複合物である PICACE® は，喫煙による DNA 酸化傷害を抑制することが示唆された． Oxidative stress is considered to contribute to degenerative disease. The urinary excretion of the DNA repair product 8-hydroxy-2′-deoxyguanosine (8-OHdG) is proposed as a noninvasive biomarker of current oxidative stress in vivo. We investigated the effect of an antioxidant mixture on urinary 8-OHdG excretions in 12 otherwise healthy smokers. During the intervention period for 2 weeks, subjects consumed four capsules of PICACE® (Pycnogenol® 15 mg/capsule, Vitamin E; 56.1 mg/capsule, Squalene; 138.9 mg/capsule) per day. On days 0 (pre-internal use), 3, 7, 14, and 44, morning urine samples were collected. The urinary 8-OHdG was measured using high-performance liquid chromatography (HPLC). The urinary 8-OHdG level on day 3 was significantly reduced compared to day 0. The level of 8-OHdG after a washout period for PICACE® (days 44) returned to day 0 baseline. These preliminary data suggest that PICACE® supplements can protect smokers from oxidative stress and possibly reduce disease risk caused by free radicals associated with smoking.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本補完代替医療学会 = The Japanese Society for Complementary and Alternative Medicine"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1625/jcam.4.33","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jcam-net.jp/index.html","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ci.nii.ac.jp/naid/130000079390","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://japanlinkcenter.org/JST.JSTAGE/jcam/4.33","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2007 日本補完代替医療学会"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA12095429","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348-7922","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大野, 智"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"大野, 由美子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, 信孝"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"川越, 信秀"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"新井, 隆成"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"井上, 正樹"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-SUZUKI-N-33.pdf","filesize":[{"value":"244.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-SUZUKI-N-33.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14527/files/ME-PR-SUZUKI-N-33.pdf"},"version_id":"6949b62e-f703-4a76-a101-c9e311c43b47"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"健常喫煙者における抗酸化天然成分によるパイロット試験：DNA 酸化傷害抑制効果の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"健常喫煙者における抗酸化天然成分によるパイロット試験：DNA 酸化傷害抑制効果の検討"},{"subitem_title":"Pilot Study of Antioxidant Mixture (Vitamin E, Pycnogenol® and Squalene) in Healthy Smokers: Inhibitory Effect on Oxidative DNA Damage","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14527","relation_version_is_last":true,"title":["健常喫煙者における抗酸化天然成分によるパイロット試験：DNA 酸化傷害抑制効果の検討"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:45:53.417739+00:00"}