{"created":"2023-07-27T06:29:46.280887+00:00","id":14534,"links":{},"metadata":{"_buckets":{"deposit":"3b348a12-c200-444b-9615-5b66719ed931"},"_deposit":{"created_by":3,"id":"14534","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14534"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014534","sets":["1132:1133:1134"]},"author_link":["21422","41"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"157","bibliographicPageStart":"153","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"Experimental Animals"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The non-coding RNA Xist is indispensable for X chromosome inactivation. Transcriptional control of Xist gene depends on its antisense partner gene Tsix which prevents Xist up-regulation in cis. Previous studies proposed Tsix acts by regulating chromatin structure. Although histone modifications in the Xist locus during differentiation have been described in female embryonic stem (ES) cells, they remain unclear in males. Here we addressed histone modifications in the Xist locus in wild-type and Tsix-mutant male ES cells during differentiation. Their active and repressive modifications were attenuated upon differentiation, while the histone modification profile in males resembled that of females in an undifferentiated condition. These results provide implications in understanding the regulation of Xist gene, as well as other developmentally regulated genes, through chromatin structure.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本実験動物学会 = Japanese Association for Laboratory Animal Science"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1538/expanim.57.153","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jalas.jp/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ci.nii.ac.jp/naid/10024166348","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://japanlinkcenter.org/JST.JSTAGE/expanim/57.153","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2008 日本実験動物学会"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11032321","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1341-1357","subitem_source_identifier_type":"ISSN"}]},"item_4_text_2":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"野生型および Tsix 遺伝子変異ES細胞の分化誘導時における Xist 遺伝子座ヒストン修飾の変化"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shibata, Shinwa"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yokota, Takashi"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-YOKOTA-T-153.pdf","filesize":[{"value":"827.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-YOKOTA-T-153.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14534/files/ME-PR-YOKOTA-T-153.pdf"},"version_id":"3e469c75-5c47-483a-b46f-ecbf3e51e3f5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Alteration of Histone Tail Modifications in the Xist Locus in Wild-Type and Tsix-Mutant Male Embryonic Stem Cells during Differentiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Alteration of Histone Tail Modifications in the Xist Locus in Wild-Type and Tsix-Mutant Male Embryonic Stem Cells during Differentiation"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14534","relation_version_is_last":true,"title":["Alteration of Histone Tail Modifications in the Xist Locus in Wild-Type and Tsix-Mutant Male Embryonic Stem Cells during Differentiation"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T17:21:20.035847+00:00"}