{"created":"2023-07-27T06:29:47.948592+00:00","id":14560,"links":{},"metadata":{"_buckets":{"deposit":"f8889ad1-7fe7-40fe-a29d-fc0e6b79e957"},"_deposit":{"created_by":3,"id":"14560","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14560"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014560","sets":["1132:1133:1134"]},"author_link":["25668","21446","25667","25661","25665","25669","25672","265","25664","25675","25662","25663","25670","25673","25674","25671","25660","25666"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"1171","bibliographicPageStart":"1163","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"Journal of Gastroenterology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Iron overload syndromes include a wide spectrum of genetic and acquired conditions. Recent studies suggest suppressed hepcidin synthesis in the liver to be the molecular basis of hemochromatosis. However, a liver with acquired iron overload synthesizes an adequate amount of hepcidin. Thus, hepcidin could function as a biochemical marker for differential diagnosis of iron overload syndromes. Methods We measured serum iron parameters and hepcidin- 25 levels followed by sequencing HFE, HJV, HAMP, TFR2, and SLC40A1 genes in 13 Japanese patients with iron overload syndromes. In addition, we performed direct measurement of serum hepcidin-25 levels using liquid chromatography-tandem mass spectrometry in 3 Japanese patients with aceruloplasminemia and 4 Italians with HFE hemochromatosis. Results One patient with HJV hemochromatosis, 2 with TFR2 hemochromatosis, and 3 with ferroportin disease were found among the 13 Japanese patients. The remaining 7 Japanese patients showed no evidence for genetic basis of iron overload syndrome. As far as the serum hepcidin-25 was concerned, seven patients with hemochromatosis and 3 with aceruloplasminemia showed markedly decreased serum hepcidin-25 levels. In contrast, 3 patients with ferroportin disease and 7 with secondary iron overload syndromes showed serum hepcidin levels parallel to their hyperferritinemia. Patients with iron overload syndromes were divided into 2 phenotypes presenting as low and high hepcidinemia. These were then associated with their genotypes. Conclusion Determining serum hepcidin-25 levels may aid differential diagnosis of iron overload syndromes prior to genetic analysis. © Springer 2010.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"石川県立中央病院","subitem_description_type":"Other"},{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00535-010-0259-8","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA10988015","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0944-1174","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kaneko, Yoshibumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyajima, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Piperno, Alberto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomosugi, Naohisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Hisao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morotomi, Natsuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuchida, Ken-ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Takaaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishikawa, Akihisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ota, Yusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wakusawa, Shinya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshioka, Kentaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kono, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Pelucchi, Sara"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hattori, Ai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tatsumi, Yasuaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okada, Toshihide"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yamagishi, Masakazu"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-KANEKO-Y-1163.pdf","filesize":[{"value":"132.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-KANEKO-Y-1163.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14560/files/ME-PR-KANEKO-Y-1163.pdf"},"version_id":"66778dce-f60e-4658-aa83-e1151b23ff7e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14560","relation_version_is_last":true,"title":["Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:45:12.328669+00:00"}