{"_buckets": {"deposit": "1c5a111b-3bf8-48ae-91c5-0c363df884ca"}, "_deposit": {"created_by": 3, "id": "14608", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "14608"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00014608", "sets": ["1134"]}, "author_link": ["362", "25869", "25868", "25873", "20454", "25874", "25871", "25870", "20455", "357", "25872"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-08-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageEnd": "456", "bibliographicPageStart": "450", "bibliographicVolumeNumber": "54", "bibliographic_titles": [{"bibliographic_title": "Journal of Human Genetics"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Numerous CpG islands containing tissue-specific differentially methylated regions (TDMRs) are potential methylation sites in normal cells and tissues. The VASA (also known as DDX4) gene is believed to be under the control of TDMRs. A total of 131 male patients with idiopathic azoospermia or severe oligospermia were evaluated histologically, and the methylation status of CpG islands in the VASA gene was screened. Genome DNAs were obtained from testicular biopsy and modified with sodium bisulfite, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was applied. This system is capable of analyzing both the methylated and unmethylated CpG island in the genome. The methylation analysis is conducted by an epigram as graphic data. On histological assessment, 17 of 131 patients revealed maturation arrest (MA).In all, 6 of the 17 patients showed particularly high VASA TDMR methylation rates, whereas the remaining 11 patients and controls had low methylation rates. This study may imply that the VASA TDMR methylation is significantly higher among patients with MA, in whom the VASA gene expression was silenced. This finding represents an important contribution to the molecular basis of meiotic arrest as one possible cause of idiopathic infertility. © 2009 The Japan Society of Human Genetics All rights reserved.", "subitem_description_type": "Abstract"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Japan Society of Human Genetics = 日本人類遺伝学会 / Springer-Verlag Tokyo"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1038/jhg.2009.59", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://jshg.jp/", "subitem_relation_type_select": "URI"}}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11206160", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1434-5161", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sugimoto, Kazuhiro"}], "nameIdentifiers": [{"nameIdentifier": "25868", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koh, Eitetsu"}], "nameIdentifiers": [{"nameIdentifier": "20455", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90283134", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90283134"}, {"nameIdentifier": "90283134", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090283134"}]}, {"creatorNames": [{"creatorName": "Sin, Ho-Su"}], "nameIdentifiers": [{"nameIdentifier": "25869", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maeda, Yuji"}], "nameIdentifiers": [{"nameIdentifier": "357", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20377394", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20377394"}, {"nameIdentifier": "20377394", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000020377394"}]}, {"creatorNames": [{"creatorName": "Narimoto, Kazutaka"}], "nameIdentifiers": [{"nameIdentifier": "25870", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Izumi, Koji"}], "nameIdentifiers": [{"nameIdentifier": "362", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80646787", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": 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"https://kaken.nii.ac.jp/ja/search/?qm=70155985"}, {"nameIdentifier": "70155985", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000070155985"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-03"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-KOH-E-450.pdf", "filesize": [{"value": "500.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 500300.0, "url": {"label": "ME-PR-KOH-E-450.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/14608/files/ME-PR-KOH-E-450.pdf"}, "version_id": "62d00838-e6a4-4f06-89a1-b86309306657"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "CpG island", "subitem_subject_scheme": "Other"}, {"subitem_subject": "DDX4", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MALDI-TOF MS", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Male infertility", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Spermatogenesis", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in the testis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in the testis"}]}, "item_type_id": "4", "owner": "3", "path": ["1134"], "permalink_uri": "http://hdl.handle.net/2297/19417", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-03"}, "publish_date": "2017-10-03", "publish_status": "0", "recid": "14608", "relation": {}, "relation_version_is_last": true, "title": ["Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in the testis"], "weko_shared_id": -1}