@article{oai:kanazawa-u.repo.nii.ac.jp:00014612,
 author = {Sugimoto, Hisashi and Ito, Makoto and Hatano, Miyako and Kondo, Satoru and Suzuki, Shioto and Yoshizaki, Tomokazu},
 issue = {3},
 journal = {Otology and Neurotology},
 month = {Apr},
 note = {Objectives: The authors recently demonstrated that extensive bone erosion correlated with a worse prognosis of the squamous cell carcinoma (SCC) of the temporal bone. The present objective was to investigate the expressions and the roles of epithelial-mesenchymal transition (EMT) in SCC of the temporal bone. Study Design: Retrospective patient file review and immunohistochemical study of tissues of patients with SCC of the temporal bone. Patients: The authors examined the expressions of vimentin in 16 patients with SCC of the temporal bone by immunohistochemical analysis. Results: As expected, vimentin was expressed on SCC of the temporal bone. We regard the patient who has vimentin-positive cells as EMT-positive patient because gain of vimentin is a hallmark in the EMT reported in several types of cancer. EMT positive tumors significantly correlated with extensive bone erosion, and extensive bone erosion correlated with a worse prognosis of the SCC of the temporal bone. Conclusion: The study results suggest that EMT in tumor cells becomes an important indicator of poor prognosis in SCC of the temporal bone. Copyright © 2011 Otology & Neurotology, Inc. Unauthorized reproduction of this article is prohibited., 金沢大学医薬保健研究域医学系},
 pages = {483--487},
 title = {Roles of epithelial-mesenchymal transition in squamous cell carcinoma of the temporal bone},
 volume = {32},
 year = {2011}
}