{"created":"2023-07-27T06:29:50.813329+00:00","id":14619,"links":{},"metadata":{"_buckets":{"deposit":"170160e5-91a5-4c04-a00e-53a101c7031b"},"_deposit":{"created_by":3,"id":"14619","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14619"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014619","sets":["1132:1133:1134"]},"author_link":["575","25904","157","25902","496","25903","166","25901"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"29","bibliographicPageStart":"22","bibliographicVolumeNumber":"107","bibliographic_titles":[{"bibliographic_title":"Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: The purpose of this study was to investigate bone morphogenetic protein (BMP) 2 expression after implantation of a statin and recombinant human BMP-2 (rhBMP-2) and to compare the bone regeneration capability of these substances in the rabbit nasal bone using immunohistologic methods. Study design: Twelve adult male Japanese white rabbits (n = 12; age 12-16 weeks, weight 2.5-3.0 kg) were divided into 3 experimental groups and 1 control group. A total of 48 bone defects, 4 per rabbit, were created in the nasal bone while preserving the nasal membrane. In the experimental groups, 1 group was implanted with 10 mg of a statin dissolved in 0.2 mL water with an atelocollagen sponge (ACS); the second group was implanted with 5 μg rhBMP-2 with an ACS; and in the third group only the ACS was implanted. No material was implanted in the control group. Animals were killed at 1, 2, and 4 weeks after surgery. The parts that had been operated on were removed and prepared for histologic assessment. The expression of BMP-2 was evaluated using immunohistochemistry, and double-immunostaining for BMP-2 and Ki-67 was observed by fluorescent microscopy. Results: No significant differences were observed between the statin/ACS group and rhBMP-2/ACS group at 1, 2, and 4 weeks after surgery. The number of cells which stained positively for BMP-2 increased significantly in both of the implanted groups compared with the control group (P < .0001). The positive fluorescent double-immunostaining for BMP-2 and Ki-67 was similar in both implanted groups. Conclusion: This study suggests that statin/ACS implants show BMP-2 expression and osteoinductive activity that is similar to those of rhBMP-2/ACS implants. © 2009 Mosby, Inc. All rights reserved..","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.tripleo.2008.06.025","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1016/j.tripleo.2008.06.025","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.elsevier.com/locate/issn/10792104","subitem_relation_type_select":"URI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11032296","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1079-2104","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Alam, Shamiul"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueki, Koichiro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Nakagawa, Kiyomasa"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Marukawa, Kohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashiba, Yukari"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Etsuhide"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Sakulsak, Natthiya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iseki, Shoichi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-UEKI-K-22.pdf","filesize":[{"value":"4.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-UEKI-K-22.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14619/files/ME-PR-UEKI-K-22.pdf"},"version_id":"d2e0307a-41c6-45e0-9d40-867317c66052"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14619","relation_version_is_last":true,"title":["Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:43:58.759511+00:00"}