{"created":"2023-07-27T06:29:50.942139+00:00","id":14622,"links":{},"metadata":{"_buckets":{"deposit":"3ce22d88-8c90-4227-84cc-242fa8add5db"},"_deposit":{"created_by":3,"id":"14622","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14622"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014622","sets":["1132:1133:1134"]},"author_link":["25912","563","20313","25913","25914","504","330","25916","118","22046","25915"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"1097","bibliographicPageStart":"1093","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Internal Medicine"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective. KL-6 is reported to be excreted from the lung alveolar and bronchial epithelial cells and may be a good marker for monitoring disease activity of interstitial pneumonia. This study was designed to ascertain the clinical significance of serum KL-6 levels in interstitial pneumonia associated with anti-neutrophil cytoplasmic antibody (ANCA)-related vasculitis. Methods. Serum KL-6 levels were determined by an enzyme-linked immunosorbent assay. Patients. We examined 20 healthy subjects, 13 patients with perinuclear (myeloperoxidase, MPO) ANCA-related vasculitis and 12 dermatomyositis (DM)/polymyositis (PM) patients as disease controls in this study. Six out of 13 patients with ANCA-related vasculitis had interstitial pneumonia. Results. Serum levels of KL-6 in ANCA-positive patients with interstitial pneumonia were significantly elevated, while they remained as low as those of healthy subjects in ANCA- positive patients without interstitial pneumonia. Similarly, KL-6 levels in sera were higher in 12 dermatomyositis/polymyositis patients with interstitial pneumonia, while they remained low in DM/PM patients without interstitial pneumonia. Moreover, the elevated serum KL-6 level was reduced during the convalescence induced by glucocorticoid therapy and reflected the disease activity of interstitial pneumonia associated with ANCA-related vasculitis. Conclusion. These data suggest that the measurement of serum KL-6 levels may be a good monitoring system for the diagnosis and follow-up of interstitial pneumonia of patients with ANCA-related vasculitis.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japanese Society of Internal Medicine = 日本内科学会"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2169/internalmedicine.40.1093","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ci.nii.ac.jp/naid/10007313731","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.naika.or.jp/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2001 by The Japanese Society of Internal Medicine"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11211604","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1080-6040","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Iwata, Yasunori"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Wada, Takashi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Furuichi, Kengo"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Kitagawa, Kiyoki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kokubo, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, Motoo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakai, Norihiko"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Yoshimoto, Keiichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu, Miho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, Kenichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yokoyama, Hitoshi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-WADA-T-1093.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-WADA-T-1093.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14622/files/ME-PR-WADA-T-1093.pdf"},"version_id":"c7ea6461-bfab-4d93-9872-186138f4de6d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Serum levels of KL-6 reflect disease activity of interstitial pneumonia associated with ANCA-related vasculitis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Serum levels of KL-6 reflect disease activity of interstitial pneumonia associated with ANCA-related vasculitis"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14622","relation_version_is_last":true,"title":["Serum levels of KL-6 reflect disease activity of interstitial pneumonia associated with ANCA-related vasculitis"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T11:49:54.509101+00:00"}