{"created":"2023-07-27T06:29:54.019432+00:00","id":14695,"links":{},"metadata":{"_buckets":{"deposit":"0d0383d1-be72-46d5-b2d9-9b50992cd3b0"},"_deposit":{"created_by":3,"id":"14695","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14695"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014695","sets":["1132:1133:1134"]},"author_link":["21834","26142","26140","199","26141","11685"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"571","bibliographicPageStart":"564","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Neurologia Medico-Chirurgica"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The relationship between the grade of astrocytic tumor and the expression of deoxyribonucleic acid methyltransferase (DNA-MTase) gene was examined. The levels of DNA-MTase messenger ribonucleic acid (mRNA) were measured by semiquantitative reverse transcriptase-polymerase chain reaction in surgical specimens from 12 astrocytic tumors (4 astrocytomas, 6 anaplastic astrocytomas, and 2 glioblastomas) and two normal brain tissues, and in four glioma cell lines. Compared to normal brain tissues, the levels of DNA-MTase mRNA were increased by 16- to 55-fold in low grade astrocytomas, and significantly increased by 200- to 4500-fold in high grade astrocytomas (anaplastic astrocytomas and glioblastomas) and more than 4500-fold in glioma cell lines. In situ hybridization with paraffin-embedded surgical specimens of human astrocytic tumors showed DNA-MTase mRNA was abundantly expressed in high grade astrocytomas. The detection of increased DNA-MTase expression in astrocytic tumor indicates involvement in the tumorigenesis and suggests that blocking of this change with specific inhibitors may offer new therapeutic strategies for malignant astrocytic tumors.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"},{"subitem_description":"金沢大学附属病院脳神経外科","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本脳神経外科学会"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2176/nmc.40.564","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://jns.umin.ac.jp/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jstage.jst.go.jp/article/nmc/40/11/40_564/_article","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright© The Japan Neurosurgical Society"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA0075470X","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0470-8105","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okada, Yoshie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okada, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nomura, Masayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Yutaka"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yamashima, Tetsumori"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yamashita, Junkoh"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-YAMASHIMA-T-564.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-YAMASHIMA-T-564.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14695/files/ME-PR-YAMASHIMA-T-564.pdf"},"version_id":"e2a09ad0-4768-4996-91cb-4e4c6fdf5ac1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Increased expression of deoxyribonucleic acid methyltransferase gene in human astrocytic tumors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Increased expression of deoxyribonucleic acid methyltransferase gene in human astrocytic tumors"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14695","relation_version_is_last":true,"title":["Increased expression of deoxyribonucleic acid methyltransferase gene in human astrocytic tumors"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:42:28.537096+00:00"}