@article{oai:kanazawa-u.repo.nii.ac.jp:00014696, author = {Sakurai, Takeshi and Mieda, Michihiro and Tsujino, Natsuko}, journal = {Bulletin of the Japanese Society of Scientific Fisheries = AN00193422}, month = {Jul}, note = {The neuropeptides orexin A and orexin B, produced in hypothalamic neurons, are critical regulators of sleep/wake states. Deficiency of orexin signaling results in narcoleptic phenotype in humans, dogs, and rodents. Recently, accumulating evidence has indicated that the orexin system regulates sleep and wakefulness through interactions with neuronal systems that are closely related with emotion, reward, and energy homeostasis. In this review, we will discuss the current understanding of the physiology of the orexin system especially focusing on its roles in the regulation of sleep/wakefulness states. © 2010 New York Academy of Sciences., 金沢大学医薬保健研究域医学系}, pages = {149--161}, title = {The orexin system: Roles in sleep/wake regulation}, volume = {1200}, year = {2010} }