@article{oai:kanazawa-u.repo.nii.ac.jp:00014710,
 author = {Shin, Ho-Su and Koh, Eitetsu and Kim, Dae-Soo and Murayama, Miho and Sugimoto, Kazuhiro and Maeda, Yuji and Yoshida, Atsumi and Namiki, Mikio},
 issue = {11},
 journal = {Journal of Human Genetics},
 month = {Nov},
 note = {The male-specific region of Y chromosome (MSY) has accumulated a higher density of human endogenous retroviruses (HERVs) and related sequences when compared with other regions of the human genome. Here, we focused on one HERV family, HERV-K14C that seemed to integrate preferentially into the Y chromosome in humans. To identify every copies of HERV-K14C in the human genome, we applied computational screening to map precisely the locus of individual HERV-K14C copies. Interestingly, 29 of all 146 copies were located in Y chromosome, and these 29 copies were mostly dispersed in the palindromic region. Three distinct HERV-K14C-related transcripts were found and were exclusively expressed in human testis tissue. Based on our phylogenetic analysis of the solitary LTRs derived from HERV-K14C on the Y chromosome we suggested that these sequences were generated as pairs of identical sequences. Specifically, analysis of HERV-K14C-related sequences in the palindromic region demonstrated that the Y chromosomal amplicons existed in our common ancestors and the duplicated pairs arose after divergence of great apes approximately 8-10 million years ago. Taken together, our observation suggested that HERV-K14C-related sequences contributed to genomic diversification of Y chromosome during speciation of great ape lineage. © 2010 The Japan Society of Human Genetics All rights reserved., 金沢大学医薬保健研究域医学系},
 pages = {717--725},
 title = {Human endogenous retrovirus K14C drove genomic diversification of the Y chromosome during primate evolution},
 volume = {55},
 year = {2010}
}