{"created":"2023-07-27T06:29:56.599855+00:00","id":14756,"links":{},"metadata":{"_buckets":{"deposit":"80cef09f-91ff-4fcc-9aec-aa02b06efe27"},"_deposit":{"created_by":3,"id":"14756","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14756"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014756","sets":["1132:1133:1134"]},"author_link":["26364","26362","26359","26366","26355","26354","184","26357","26358","26361","26365","26367","26356","26363","118","26360","20313"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1352","bibliographicPageStart":"1345","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Investigation"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A disintegrin and metalloproteinase (ADAM) represents a protein family possessing both metalloproteinase and disintegrin domains. ADAMTS-1, an ADAM family member cloned from cachexigenic colon adenocarcinoma, is unusual in that it contains thrombospondin type I motifs and anchors to the extracellular matrix. To elucidate the biological role of ADAMTS-1, we developed ADAMTS-1-null mice by gene targeting. Targeted disruption of the mouse ADAMTS-1 gene resulted in growth retardation with adipose tissue malformation. Impaired female fertilization accompanied by histological changes in the uterus and ovaries also resulted. Furthermore, ADAMTS-1(-/-) mice demonstrated enlarged renal calices with fibrotic changes from the ureteropelvic junction through the ureter, and abnormal adrenal medullary architecture without capillary formation. ADAMTS-1 thus appears necessary for normal growth, fertility, and organ morphology and function. Moreover, the resemblance of the renal phenotype to human ureteropelvic junction obstruction may provide a clue to the pathogenesis of this common congenital disease.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Clinical Investigation"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1172/JCI8635","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jci.org/articles/view/8635","subitem_relation_type_select":"URI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00695520","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-9738","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shindo, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurihara, Hiroki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuno, Kouji"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yokoyama, Hitoshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Wada, Takashi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Kurihara, Yukiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imai, Tomihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wang, Yuhui"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogata, Masafumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishimatsu, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moriyama, Nobuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oh-hashi, Yoshio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morita, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishikawa, Takatoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagai, Ryozo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yazaki, Yoshio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsushima, Kouji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-WADA-T-1345.pdf","filesize":[{"value":"5.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-WADA-T-1345.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14756/files/ME-PR-WADA-T-1345.pdf"},"version_id":"d0c5b0a9-a2a1-4f9b-a946-d32eae08b65b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ADAMTS-1: A metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ADAMTS-1: A metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14756","relation_version_is_last":true,"title":["ADAMTS-1: A metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:41:23.075958+00:00"}