{"created":"2023-07-27T06:29:57.030842+00:00","id":14766,"links":{},"metadata":{"_buckets":{"deposit":"c47b717a-ab6c-4dc9-a4e3-3bd72f11fbe6"},"_deposit":{"created_by":3,"id":"14766","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14766"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014766","sets":["1132:1133:1135"]},"author_link":["26398","21834","22233","263","640","21831","26397","26399","935","26400"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-08-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"363","bibliographicPageStart":"358","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"病院薬学"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A fully automated enzyme immunoassay system, Omni (BIO-TEK Co.) (ELISA system), using Markit-M Excegran and Markit-M Haloperidol (Dainippon Pharmaceutical Co.) was evaluated to determine the concentrations of zonisamide (ZNS) and haloperidol (HP) in human plasma. At first, the within-run (ZNS : n=8, HP : n=10) and the between-run (4 days) precisions of ZNS and HP were examined. The coefficient of the variations in both the within-run and the between-run previsions of HP were below 5.0 and 7.00/0, respectively. In contrast, the some values of ZNS were below 6.5 and 8.40/0, respectively. A good correlation was observed between this ELISA system and HPLC (r=0.917), which was used to determine the plasma ZNS concentration. In the case of HP, a good correlation was seen between this ELISA system and the manual ELISA method (r=0.978). This method was thus used to monitor the serum levels in patients receiving ZNS or HP therapy. The relationship was observed between the daily dose (mg/kg) and the plasma concentration of the trough level for ZNS and HP, respectively (r=0.750 p<0.001, r= 0.669 p<0.001). However, the ratio of the plasma concentration of ZNS and the daily dose increased significantly with aging.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院自然科学研究科分子作用学","subitem_description_type":"Other"},{"subitem_description":"金沢大学医学部附属病院薬剤部","subitem_description_type":"Other"},{"subitem_description":"金沢大学大学院医学系研究科","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本医療薬学会"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0389-9098","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石崎, 純子"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"横川, 弘一"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"中島, 恵美"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"古田, 壽一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"越野, 好文"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"関, 秀俊"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"谷口, 昂"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"長谷川, 光広"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"山下, 純宏"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"市村, 藤雄"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"PH-PR-ISHIZAKI-J-358.pdf","filesize":[{"value":"598.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PH-PR-ISHIZAKI-J-358.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14766/files/PH-PR-ISHIZAKI-J-358.pdf"},"version_id":"34979c4f-1695-47bc-90ad-dd50c563c5dd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"全自動ELISAシステムによるゾニサミドおよびハロペリドールの血漿中濃度測定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"全自動ELISAシステムによるゾニサミドおよびハロペリドールの血漿中濃度測定"},{"subitem_title":"Determination of Zonisamide and Haloperidol in Plasma by Using a Fully Automated ELISA System","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14766","relation_version_is_last":true,"title":["全自動ELISAシステムによるゾニサミドおよびハロペリドールの血漿中濃度測定"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:41:13.429182+00:00"}