{"created":"2023-07-27T06:29:58.551584+00:00","id":14802,"links":{},"metadata":{"_buckets":{"deposit":"96ed9ee8-f43f-4167-9feb-b13ae5c668b8"},"_deposit":{"created_by":3,"id":"14802","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14802"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014802","sets":["1132:1133:1135"]},"author_link":["26502","26369","26500","26499","26501"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1983-08-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"2592","bibliographicPageStart":"2583","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"Chemical & pharmaceutical bulletin"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The first total synthesis of alangicine (3), an Alangium lamarckii alkaloid, has been achieved in the form of a racemic modification by means of an initial alkaline hydrolysis of the (±)-tricyclic ester 6 and succeeding steps proceeding through the intermediates (±)-7,(±)-10,and (±)-9. A parallel synthetic route starting with the (-)-tricyclic ester 6,derived from (+)-cincholoipon ethyl ester (8), produced the chiral target molecule (+)-3 with alangicine unequivocally established the structure and absolute stereochemistry of this alkaloid. The ^<13>C nuclear magnetic resonance spectra of (±)-alangicine (3) and the ipecac and Alangium alkaloid psychotrine (18) confirmed their endocyclic double bond structures in the dihydroisoquinoline moiety. Catalytic reductions of 11,(±)-12,and 15 using hydrogen and Pd-C were investigated, and the results have shown that hydrogenolysis of the benzyloxy group proceeds much faster than saturation of the endocyclic C=N bond.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/cpb.31.2583","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00602100","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0009-2363","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujii, Tozo"}],"nameIdentifiers":[{"nameIdentifier":"26499","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Koichiro"}],"nameIdentifiers":[{"nameIdentifier":"26500","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minami, Shinzaburo"}],"nameIdentifiers":[{"nameIdentifier":"26501","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshifuji, Shigeyuki"}],"nameIdentifiers":[{"nameIdentifier":"26502","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohba, Masashi"}],"nameIdentifiers":[{"nameIdentifier":"26369","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60115219","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60115219"},{"nameIdentifier":"60115219","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000060115219"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"PH-PR-OHBA-M-2583.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PH-PR-OHBA-M-2583.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14802/files/PH-PR-OHBA-M-2583.pdf"},"version_id":"98b6bfa1-0ddc-4892-9c5a-ff51cc0a53f7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Quinolizidines. VIII. Structure and Synthesis of the Alangium Alkaloid Alangicine : Syntheses of (±)- and (+)-Alangicines","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Quinolizidines. VIII. Structure and Synthesis of the Alangium Alkaloid Alangicine : Syntheses of (±)- and (+)-Alangicines"}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14802","relation_version_is_last":true,"title":["Quinolizidines. VIII. Structure and Synthesis of the Alangium Alkaloid Alangicine : Syntheses of (±)- and (+)-Alangicines"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2024-06-20T06:56:09.095030+00:00"}