{"created":"2023-07-27T06:29:59.069608+00:00","id":14814,"links":{},"metadata":{"_buckets":{"deposit":"08da299a-1a26-472b-9dca-8c887943c314"},"_deposit":{"created_by":3,"id":"14814","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14814"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014814","sets":["1132:1133:1135"]},"author_link":["26530","22233","26532","640","26529","26531"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"329","bibliographicPageStart":"322","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"病院薬学"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Analysis of fasting effect on biperiden distribution in rats was examined. The plasma concentration at 24hr after i. v. injection of 3.2 mg/kg varied between 0.4 ng/ml (10-week-old fasted rats) and 1.4 ng/ml (10-week-old normal rats). The steady state distribution volume of biperiden in the fasted rats was smaller by 2/3 than that in the normal rats. The determined percentage of fat tissue per body weight reduced from 7.6 to 2.35 was caused by fasting. There was a good cerrelation between the steady state distribution volume of biperiden per lean mass body weight and the fat volume per lean mass body weight (r=0.989) in four different groups (10-week-old fasted 4-, 10-, and 50-week-old normal rats). The fat/plasma concentration ratios at 8hr after the i. v. injection varied between 380 (10-week-old normal rats) and 550 (10-week-old fasted rats), whereas the brain/plasma concentration ratios were identical to those at steady state among the two groups. The time courses of biperiden concentration in plasma, brain, and fat were simulated using a physiological pharmacokinetic model. There was reasonable agreement between the model predictions and the observed data, suggesting that the change in the fat volume is a dominant determinant of the distribution volume of biperiden in rats. Changes in fasted tissue and plasma concentrations are discussed in relation to the clinical usefulness of the blood level monitoring.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"大学院自然科学研究科分子作用学","subitem_description_type":"Other"},{"subitem_description":"金沢大学医学部付属病院薬剤部","subitem_description_type":"Other"},{"subitem_description":"金沢大学大学院医学系研究科","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本医療薬学会"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0389-9098","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石崎, 純子"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"横川, 弘一"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"中島, 恵美"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"永野, 耐造"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"前田, 均"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"市村, 藤雄"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"PH-PR-ISHIZAKI-J-322.pdf","filesize":[{"value":"828.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PH-PR-ISHIZAKI-J-322.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14814/files/PH-PR-ISHIZAKI-J-322.pdf"},"version_id":"97b1f182-dd90-4416-8f7a-4b878877124f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"絶食時のラットを用いたビペリデンの体内動態変動要因の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"絶食時のラットを用いたビペリデンの体内動態変動要因の解析"},{"subitem_title":"Analysis of Fasting Effect on Biperiden Distribution Kinetics in Rats","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14814","relation_version_is_last":true,"title":["絶食時のラットを用いたビペリデンの体内動態変動要因の解析"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:41:00.291433+00:00"}