@article{oai:kanazawa-u.repo.nii.ac.jp:00014837,
 author = {Fujii, Tozo and Saito, Toru and Chikazawa, Jun and Nakamura, Yuko and Ohba, Masashi},
 issue = {12},
 journal = {Chemical & pharmaceutical bulletin},
 month = {Feb},
 note = {Four-step synthetic routes from 3-methyladenine (10) to 7-benzyl-N6,3-dimethyladenine (1b) and 7-benzyl-1,2-dihydro-1,3-dimethyladenine (2b), selected as models for the marine sponge alkaloids agelasimine-A (1a) and agelasimine-B (2a), respectively, have been established. The key steps involved are regioselective methylations of 7-benzyl-3-methyladenine (8) and 7-benzyl-1,2-dihydro-3-methyladenine (11). The reaction of 1b with acetic anhydride in pyridine was found to give the monocyclic imidazole derivative 29b. A similar acetylation of 2b yielded the N6-acetyl derivative 20b. When treated with boiling H2O, 20b afforded 7-benzyl-2,3-dimethylhypoxanthine (21b) and a compound inferred to be the dihydrohypoxanthine derivative 30. Probable pathways to 29b from 1b and to 21b and 30 from 20b are proposed.},
 pages = {2461--2466},
 title = {Purines. LXV. Preparatory study for the syntheses of the marine sponge purines agelasimines-A and -B: Synthesis and acetylation of their N(7)-benzyl analogues},
 volume = {42},
 year = {1994}
}