{"created":"2023-07-27T06:30:00.226551+00:00","id":14841,"links":{},"metadata":{"_buckets":{"deposit":"a420d96d-289d-4649-acc3-db80285d4e95"},"_deposit":{"created_by":3,"id":"14841","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14841"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014841","sets":["1132:1133:1135"]},"author_link":["354","26603","344","26602","26601","26604","26600"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-04-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"17","bibliographicPageEnd":"1563","bibliographicPageStart":"1553","bibliographicVolumeNumber":"80","bibliographic_titles":[{"bibliographic_title":"Life Sciences"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We investigated the effects of red pepper (Capsicum annuum Lin.) extracts (capsicum extract) and its main pungent capsaicin on T helper 1 (Th1) and 2 (Th2) cytokine production in cultured murine Peyer's patch (PP) cells in vitro and ex vivo. Direct administration of capsicum extract (1 and 10 μg/ml) and capsaicin (3 and 30 μM) resulted in suppression of interleukin (IL)-2, interferon (IFN)-γ, IL-4 and IL-5 production. In an ex vivo experiment using PP cells removed from the mice after oral administration of capsicum extract (10 mg/kg/day for 4 consecutive days), IL-2, IFN-γ and IL-5 increased in response to concanavalin A (Con A). Oral administration of 3 mg/kg/day capsaicin, one active constituent of the extract, also enhanced IL-2, INF-γ and IL-4 production in response to Con A stimulation but did not influence the production of IL-5. Orally administered capsazepine (3 mg/kg/day), a selective transient receptor potential vanilloid 1 (TRPV1) antagonist, slightly enhanced IL-2 production also irrespective of Con A stimulation. The capsaicin-induced enhancement of both IL-2 and IFN-γ production was not reduced by oral administration of capsazepine (3 mg/kg/day), suggesting a TRPV1 receptor-independent mechanism. Flow cytometric analysis revealed that the population of CD3+ cells in the PP cells was significantly reduced while CD19+ cells increased after oral administration of capsicum extract (1 and 10 mg/kg/day) and capsaicin (0.3 and 3 mg/kg/day). Capsazepine (3 mg/kg/day) weakly but significantly reversed these effects. Orally administered capsicum extract and capsaicin did not change the T cell subset (CD4+ and CD8+), Th1 (IFN-γ+) and T2 (IL-4+) ratio. These findings indicate that capsicum extract and capsaicin modulate T cell-immune responses, and their immunomodulatory effects on murine PP cells are partly due to both TRPV1-dependent and -independent pathway. © 2007 Elsevier Inc. All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院自然科学研究科生理活性物質科学","subitem_description_type":"Other"},{"subitem_description":"金沢大学薬学部","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.lfs.2007.01.031","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.elsevier.com/locate/issn/00243205","subitem_relation_type_select":"URI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0024-3205","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takano, Fumihide"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yamaguchi, Masaya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takada, Satoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shoda, Satoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yahagi, Nobuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Tomoya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohta, Tomihisa"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"PH-PR-TAKANO-F-1197.pdf","filesize":[{"value":"828.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PH-PR-TAKANO-F-1197.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14841/files/PH-PR-TAKANO-F-1197.pdf"},"version_id":"fdd6c2c2-db36-4d52-9fc4-3f341d3e0ac2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Capsicum ethanol extracts and capsaicin enhance interleukin-2 and interferon-gamma production in cultured murine Peyer's patch cells ex vivo","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Capsicum ethanol extracts and capsaicin enhance interleukin-2 and interferon-gamma production in cultured murine Peyer's patch cells ex vivo"}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14841","relation_version_is_last":true,"title":["Capsicum ethanol extracts and capsaicin enhance interleukin-2 and interferon-gamma production in cultured murine Peyer's patch cells ex vivo"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T12:24:50.137718+00:00"}