{"created":"2023-07-27T06:30:00.438147+00:00","id":14846,"links":{},"metadata":{"_buckets":{"deposit":"952ee5c4-d8f9-46a7-b5a6-17e77038a340"},"_deposit":{"created_by":3,"id":"14846","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14846"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014846","sets":["1132:1133:1135"]},"author_link":["475","21551","26611","26612","26610","26609","336","26613","26608"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"380","bibliographicPageStart":"374","bibliographicVolumeNumber":"356","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ras-GTPase-activating proteins (Ras-GAPs) have been implicated both as suppressors of Ras and as effectors in regulating cellular activities. To study whether Ras-GAPs have roles in tumor cell survival or not, mRNA levels of ras-related genes were measured in v-Ki-ras-transformed (DT) and the parental NIH/3T3 cells, using real-time PCR. mRNA levels of p120-Gap, Gap1m, and PIK3CA were increased in DT cells compared with NIH/3T3 cells. p120-Gap and PIK3CA genes were induced by addition of serum or epidermal growth factor to serum-starved DT cells. Three anti-cancer drugs, an ERK kinase (MEK) inhibitor PD98059, a topoisomerase II poison doxorubicin (adriamycin), and a histone deacetylase inhibitor trichostatin A, selectively blocked the overexpression of p120-Gap and Gap1m genes in DT cells. These drugs also caused reversion of DT cells to the adherent shape associated with growth arrest. Our results suggest that p120-Gap and Gap1m genes provide important biomarkers for cancer therapies. © 2007 Elsevier Inc. All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科脳細胞分子学","subitem_description_type":"Other"},{"subitem_description":"金沢大学薬学部","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bbrc.2007.02.133","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hashii, Minako"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Fukuda, Mitsunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nomura, Hideki"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Ito, Naoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Hiroto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hattori, Seisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mikoshiba, Katsuhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Noda, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higuchi, Yoshihiro"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"PH-PR-HASHI-M-374.pdf","filesize":[{"value":"623.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PH-PR-HASHI-M-374.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14846/files/PH-PR-HASHI-M-374.pdf"},"version_id":"10e88081-4e66-40ff-bd92-01f53ebeb986"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts"}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14846","relation_version_is_last":true,"title":["Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T12:25:09.538565+00:00"}