@article{oai:kanazawa-u.repo.nii.ac.jp:00014873, author = {Ohba, Masashi and Imasho, M. and Fujii, Tozo}, issue = {1}, journal = {Chemical & pharmaceutical bulletin}, month = {Jan}, note = {A chiral synthetic route to the amino esters 5 and 6, which contain the fundamental framework of ent-imbricatine (ent-3), has been developed as a prelude to the total synthesis of the starfish alkaloid imbricatine (3). The route started from the sulfur-containing L-phenylalanine derivative 7 and proceeded through key steps such as cyclization of the amide 8 without racemization, reduction to the 1,3-cis-tetrahydroisoquinoline 9, and introduction of a chiral α-amino acid moiety into the chloride 18 by the 'bis-lactim ether' method.}, pages = {83--89}, title = {Synthetic studies on the starfish alkaloid imbricatine. Construction of an ent-imbricatine framework}, volume = {47}, year = {1999} }