@article{oai:kanazawa-u.repo.nii.ac.jp:00014874,
 author = {Mitamura, Kuniko and Horikawa, Aki and Yamane, Yuko and Ikeda, Yukari and Shimada, Kazutake},
 issue = {9},
 journal = {Biological and Pharmaceutical Bulletin},
 month = {Sep},
 note = {A method for the determination of digoxin in human serum using a liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS) technique is reported. Digoxin and the internal standard, [21,21,22- 2H3]digoxin, were extracted from 250 μl of human serum using a solid phase extraction cartridge (Oasis HLB) and analyzed by LC/ESI-MS/MS in the selected reaction monitoring mode. The intra- and interassay reproducibility and accuracy were satisfactory within the quantification range of 0.20-3.20 ng/ml. The concentrations of digoxin in the serum samples obtained from digitalized patients (n=19) were in the range of 0.25-2.84 ng/ml, which were compared to those obtained by radioimmunoassay. © 2007 Pharmaceutical Society of Japan., 金沢大学大学院自然科学研究科分子作用学, 金沢大学薬学部},
 pages = {1653--1656},
 title = {Determination of digoxin in human serum using stable isotope dilution liquid chromatography/electrospray ionization-tandem mass spectrometry},
 volume = {30},
 year = {2007}
}